Residential Proximity to Naturally Occurring Asbestos and Mesothelioma Risk in California

Details

• Personal Author:
  Beckett LA ; Day HW ; Pan XL ; Schenker MB ; Wang W
• Description:
  Rationale: Little is known about environmental exposure to low levels of naturally occurring asbestos (NOA) and malignant mesothelioma (MM) risk. OBJECTIVES: To conduct a cancer registry-based case control study of residential proximity to NOA with MM in California. Methods: Incident MM cases (n = 2,908) aged 35 yr or more, diagnosed between 1988 and 1997, were selected from the California Cancer Registry and frequency matched to control subjects with pancreatic cancer (n = 2,908) by 5-yr age group and sex. Control subjects were selected by stratified random sampling from 28,123 incident pancreatic cancers in the same time period. We located 93.7% of subjects at the house or street level at initial diagnosis. Individual occupational exposure to asbestos was derived from the longest held occupation, available for 74% of MM cases and 63% of pancreatic cancers. Occupational exposure to asbestos was determined by a priori classification and confirmed by association with mesothelioma. Main results: The adjusted odds ratios and 95% confidence interval for low, medium, and high probabilities of occupational exposures to asbestos were 1.71 (1.32-2.21), 2.51 (1.91-3.30), and 14.94 (8.37-26.67), respectively. Logistic regression analysis from a subset of 1,133 mesothelioma cases and 890 control subjects with pancreatic cancer showed that the odds of mesothelioma decreased approximately 6.3% for every 10 km farther from the nearest asbestos source, an odds ratio of 0.937 (95% confidence interval = 0.895-0.982), adjusted for age, sex, and occupational exposure to asbestos. Conclusions: These data support the hypothesis that residential proximity to NOA is significantly associated with increased risk of MM in California. [Description provided by NIOSH]
• Subjects:
  Asbestos Environmental Exposure Environmental Pollution Epidemiology Inorganic Chemicals Lung Neoplasms Occupational Health Respiratory System Risk Assessment Safety

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• Keywords:
  Asbestos Fibers Asbestosis Cancer Rates Environmental Exposure Environmental Pollution Lung Irritants Mesothelial Cells Risk Analysis
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  172
• Issue:
  8
• NIOSHTIC Number:
  nn:20033324
• Citation:
  Am J Respir Crit Care Med 2005 Oct; 172(8):1019-1025
• Contact Point Address:
  Xue-lei Pan, Department of Public Health Sciences, University of California at Davis, Davis, CA 95616-8638
• Email:
  mbschenker@ucdavis.edu
• CAS Registry Number:
  Asbestos (CAS RN 1332-21-4)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California - Davis
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bcc1c6d988e189ad023e62140d58e6521922d831a24fc38386cb9271fbf623c09c590968ec37ec7bd2dca1d21ad762e42026a8460b1de01b96636c77dac31ecb
• Download URL:
  https://stacks.cdc.gov/view/cdc/188948/cdc_188948_DS1.pdf
• File Type:
  [PDF - 221.97 KB ]