Thermoregulation and Its Influence on Toxicity Assessment

Details

• Personal Author:
  Gordon CJ ; Hinderliter PM ; Hotchkiss J ; Miller DB ; Pauluhn J ; Spencer PJ
• Description:
  The thermoregulatory system of laboratory rodents is susceptible to a variety of chemical toxicants. Because temperature directly affects the reaction of virtually all biological processes, it is critical to consider how changes in the thermoregulatory response to a toxicant may affect physiological, behavioral, and pathological endpoints. Researchers in industry and government laboratories are often faced with addressing how changes in body temperature of their experimental subjects may affect the outcome of a particular toxicity test and/or screening panel. However, many toxicologists are either unaware of the importance or ignore the potential impact of a toxic-induced change in body temperature. This paper endeavors to summarize the importance of thermoregulation in the study of toxicology and propose recommendations for thermometry that researchers may utilize in their toxicological studies. [Description provided by NIOSH]
• Subjects:
  Behavior Biological Products Environmental Monitoring Laboratories Occupational Health Safety Temperature Toxicology Workplace
• Keywords:
  Biological-agents Biological-monitoring Exposure-assessment Laboratory-animals Physiological-measurements Physiological-stress Temperature-control Temperature-effects Toxicopathology Work-areas Work-environment

  More +
• ISSN:
  0300-483X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Michigan ; North Carolina ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; Washington ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  87-97
• Volume:
  244
• Issue:
  2
• NIOSHTIC Number:
  nn:20033266
• Citation:
  Toxicology 2008 Feb; 244(2-3):87-97
• Contact Point Address:
  Christopher J. Gordon, Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, B105-04, U.S. Environmental Protection Agency, 109 S.T.W. Alexander Drive, Research Triangle Park, NC 27711
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Services
• Peer Reviewed:
  True
• Source Full Name:
  Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:43a795c0f32f7d8113e5a79f04ad7ec20ecca9b875145d823d3c72d4fed11b6d503c2e3ee5a99f1cf9f37a9c4531d8625c49db6fed15c63ede22dda9762abe21
• Download URL:
  https://stacks.cdc.gov/view/cdc/188914/cdc_188914_DS1.pdf
• File Type:
  [PDF - 803.35 KB ]