Lead Burden and Psychiatric Symptoms and the Modifying Influence of the Delta-Aminolevulinic Acid Dehydratase (ALAD) Polymorphism: The VA Normative Aging Study

Details

• Personal Author:
  Bellinger DC ; Hu H ; Kelsey KT ; Nie H ; Rajan P ; Schwartz JD ; Smith, Thomas J. ; Sparrow D ; Spiro A 3rd ; Weuve J ; Wright RO
• Description:
  The authors evaluated the association between lead burden and psychiatric symptoms and its potential modification by a delta-aminolevulinic acid dehydratase (ALAD) polymorphism. Lead measurements in blood or bone and self-reported ratings on the Brief Symptom Inventory from 1991 to 2002 were available for 1,075 US men participating in the Department of Veterans Affairs (VA) Normative Aging Study. The authors estimated the prevalence odds ratio for the association between interquartile-range lead and abnormal symptom score, adjusting for potential confounders. An interquartile increment in tibia lead (14 microg/g) was associated with 21% higher odds of somatization (95% confidence interval of the odds ratio: 1.01, 1.46). An interquartile increment in patella lead (20 microg/g) corresponded to a 23% increase in the odds of global distress (95% confidence interval of the odds ratio: 1.02, 1.47). An interquartile increment in blood lead (2.8 microg/dl) was associated with 14% higher odds of hostility (95% confidence interval of the odds ratio: 1.02, 1.27). In all other analyses, lead was nonsignificantly associated with psychiatric symptoms. The adverse association of lead with abnormal mood scores was generally stronger among ALAD 1-1 carriers than 1-2/2-2 carriers, particularly regarding phobic anxiety symptoms (p(interaction) = 0.004). These results augment evidence of a deleterious association between lead and psychiatric symptoms. [Description provided by NIOSH]
• Subjects:
  Age Factors Aging Blood Delivery Of Health Care Health Care Facilities Workforce And Services Hematologic Tests Lead Lead Poisoning Mental Disorders Mental Health Occupational Health Risk Assessment Risk Factors Safety

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• Keywords:
  Age-factors Age-groups Blood-analysis Blood-sampling Blood-tests Cell-metabolism Cell-morphology Cellular-reactions Lead-absorption Lead-compounds Lead-poisoning Medical-care Medical-monitoring Military-personnel Physical-chemistry Physical-reactions Physiological-chemistry Physiological-disorders Physiological-effects Physiological-factors Physiological-function Physiological-measurements Physiological-response Physiopathology Psychological-disorders Psychological-factors Psychological-reactions Psychological-responses Risk-factors

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  166
• Issue:
  12
• NIOSHTIC Number:
  nn:20033207
• Citation:
  Am J Epidemiol 2007 Dec; 166(12):1400-1408
• Contact Point Address:
  Dr. Pradeep Rajan, Bureau of Environmental Disease Prevention, Division of Environmental Health, New York City Department of Health and Mental Hygiene, 253 Broadway, 12th Floor, CN #58, New York, NY 10007
• Email:
  prajan@health.nyc.gov
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:9fcb385ff1e4d492e7e7b2cc9083a7b0a254be7e7d80099d552ae9b277cbe8c2b8a981d0ee41cd266de807a2ace0e20415c70d098a1a4f092885bb6e1bd12e0a
• Download URL:
  https://stacks.cdc.gov/view/cdc/188875/cdc_188875_DS1.pdf
• File Type:
  [PDF - 137.98 KB ]