Evaluating the Toxicity of Airborne Particulate Matter and Nanoparticles by Measuring Oxidative Stress Potential – a Workshop Report and Consensus Statement

Details

• Personal Author:
  Ayres JG ; Baeza-Squiban A ; Borm P ; Cassee F ; Castranova, Vincent ; Cho A ; Donaldson K ; Duggan S ; Froines J ; Ghio A ; Harrison RM ; Hider R ; Kelly F ; Kooter I ; Marano F ; Maynard RL ; Mudway I ; Nel A ; Sioutas C ; Smith S
• Description:
  Background: There is a strong need for laboratory in vitro test systems for the toxicity of airborne particulate matter and nanoparticles. The measurement of oxidative stress potential offers a promising way forward. Objectives: a workshop was convened involving leading workers from the field in order to review the available test methods and to generate a Consensus Statement. Discussions: workshop participants summarised their own research activities as well as discussion of the relative merits of different test methods. Conclusions: in vitro test methods have an important role to play in the screening of toxicity in airborne particulate matter and nanoparti- cles. In vitro cell challenges were preferable to in vitro acellular systems but both have a potential major role to play and offer large cost advantages relative to human or animal inhalation studies and animal in vivo installation experiments. There remains a need to compare tests one with another on standardised samples and also to establish a correlation with the results of population-based epidemiology. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution, Indoor Dust Environmental Monitoring Hazardous Substances Occupational Health Oxidants Particulate Matter Safety
• Keywords:
  Air-contamination Air-quality-measurement Air-samples Air-sampling-techniques Airborne-dusts Airborne-particles Analytical-methods Cell-biology Cell-differentiation Cellular-reactions Dust-analysis Dust-exposure Nanotechnology Oxidative-metabolism Particle-aerodynamics Particulate-dust Particulate-sampling-methods Particulates Sampling Sampling-methods Toxic-effects

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• ISSN:
  0895-8378
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; North Carolina ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  75-99
• Volume:
  20
• Issue:
  1
• NIOSHTIC Number:
  nn:20033191
• Citation:
  Inhal Toxicol 2008 Jan; 20(1):75-99
• Contact Point Address:
  Roy M. Harrison, Division of Environmental Health & Risk Management, School of Geography, Earth & Environmental Sciences, Edgbaston, Birmingham B15 2TT, UK
• Email:
  r.m.harrison@bham.ac.uk
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Inhalation Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d02cb79d68577f3ec024a78e5476356617cc1166ff60f11b253c1cd083e9425bb54a9414b10573f37b3c1d54b42922eb4d787b49d80eb9be76e30feec3d6f5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/188864/cdc_188864_DS1.pdf
• File Type:
  [PDF - 6.25 MB ]