Confidence Interval Construction for Relative Toxicity Endpoints Such as LD50 or LD90 Ratios

Details

• Personal Author:
  Bailer AJ ; Fadel W ; Robertson J ; Wheeler M
• Description:
  A common measure of the relative toxicity is the ratio of median lethal doses for responses estimated in two bioassays. Robertson and Preisler previously proposed a method for constructing a confidence interval for the ratio. The applicability of this technique in common experimental situations, especially those involving small samples, may be questionable because the sampling distribution of this ratio estimator may be highly skewed. To examine this possibility, we did a computer simulation experiment to evaluate the coverage properties of the Robertson and Preisler method. The simulation showed that the method provided confidence intervals that performed at the nominal confidence level for the range of responses often observed in pesticide bioassays. Results of this study provide empirical support for the continued use this technique. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biological Products Ecology Insecticides Occupational Health Risk Assessment Safety
• Keywords:
  Analytical-models Biological-agents Biological-factors Ecological-systems Mathematical-models Pesticides Risk-analysis Statistical-analysis Toxic-dose
• ISSN:
  0022-0493
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  California ; Ohio ; OSHA Region 5 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  100
• Issue:
  6
• NIOSHTIC Number:
  nn:20033186
• Citation:
  J Econ Entomol 2007 Dec; 100(6):1945-1949
• Contact Point Address:
  M Wheeler, NIOSH, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  mwheeler@cdc.gov
• Federal Fiscal Year:
  2008
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Economic Entomology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e9336f89fbf941c76012377e6814d607ba201aaec400ed71192bdf088cfa62a20ea60405606a7de7976c9b98d91b5fe8e5124c52e1e3750a7e9f2d1813ba2acb
• Download URL:
  https://stacks.cdc.gov/view/cdc/188861/cdc_188861_DS1.pdf
• File Type:
  [PDF - 125.33 KB ]