The Use of Biologically Based Cancer Risk Models in Radiation Epidemiology

Details

• Personal Author:
  Garner MJ ; Hazelton WD ; Krewski D ; Moolgavkar SH ; Zielinski JM
• Description:
  Biologically based risk projection models for radiation carcinogenesis seek to describe the fundamental biological processes involved in neoplastic transformation of somatic cells into malignant cancer cells. A validated biologically based model, whose parameters have a direct biological interpretation, can also be used to extrapolate cancer risks to different exposure conditions with some confidence. In this article, biologically based models for radiation carcinogenesis, including the two-stage clonal expansion (TSCE) model and its extensions, are reviewed. The biological and mathematical bases for such models are described, and the implications of key model parameters for cancer risk assessment examined. Specific applications of versions of the TSCE model to important epidemiologic datasets are discussed, including the Colorado uranium miners' cohort; a cohort of Chinese tin miners; the lifespan cohort of atomic bomb survivors in Hiroshima and Nagasaki; and a cohort of over 200,000 workers included in the National Dose Registry (NDR) of Canada. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biological Warfare Agents Hazardous Substances Occupational Health Radiation Radiation Injuries Risk Assessment Risk Factors Safety Uranium
• Keywords:
  Biohazards Biological-effects Biological-factors Biological-monitoring Biological-systems Biological-warfare-agents Biological-weapons Mathematical-models Radiation-contamination Radiation-effects Radiation-exposure Radiation-hazards Radiation-injury Radiation-measurement Radiation-monitoring Radiation-sickness Radiation-sources Risk-analysis Risk-factors Uranium-mining

  More +
• ISSN:
  0144-8420
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  367-376
• Volume:
  104
• Issue:
  4
• NIOSHTIC Number:
  nn:20033043
• Citation:
  Radiat Prot Dosim 2003 Jan; 104(4):367-376
• Contact Point Address:
  Audrey A. Reichard, NIOSH, Center for Disease Control & Prevention, Division of Safety Research, 1095 Willowdale Rd, MS H1808, Morgantown, WV 26505
• Email:
  stherien@uottawa.ca
• Federal Fiscal Year:
  2003
• Performing Organization:
  Fred Hutchinson Cancer Research Center
• Peer Reviewed:
  True
• Start Date:
  20020930
• Source Full Name:
  Radiation Protection Dosimetry
• End Date:
  20050929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:61480c0c9d042562bf785c2953a1ead51b6c8f56050d0a6995462778b5691f61b0fe7c8289d69e217afdb517928592c3068f2cf27a8284f23a7d58a3f08a3de9
• Download URL:
  https://stacks.cdc.gov/view/cdc/188769/cdc_188769_DS1.pdf
• File Type:
  [PDF - 229.83 KB ]