A Shope Fibroma Virus PYRIN-Only Protein Modulates the Host Immune Response

Details

• Personal Author:
  Bryan NB ; Dorfleutner A ; Flynn DC ; Funya KN ; Reed JC ; Rellick SL ; Rojanasakul Y ; Shi X ; Stehlik C ; Talbott SJ
• Description:
  PYRIN domain (PYD) proteins have recently emerged as important signaling molecules involved in the development of innate immunity to intracellular pathogens through activation of inflammatory mediator pathways. ASC is the central adaptor protein, which links pathogen recognition by PYD-containing pathogen recognition receptors to the activation of downstream effectors, including activation of Caspase-1 and NF-kappa B. The cellular PYD-only protein 1 (cPOP1) can block the recruitment of ASC to activated PAN receptors and thereby functions as an endogenous inhibitor of the PYD-mediated signal transduction pathway. Here we describe the identification and characterization of a Shope Fibroma homolog to cPOP1. Like cPOP1, a Shope Fibroma virus-encoded POP (vPOP), co-localizes and directly associates with ASC and inhibits PYD-mediated signal transduction. Poxviruses are known to encode immune evasive proteins to promote host cell infection and suppression of the host immune response. Poxvirus-encoded vPOPs represent a novel class of immune evasive proteins and impair the host response by blocking Cryopyrin and ASC inflammasome-mediated activation of pro-Caspase-1 and subsequent processing of pro-interleukin (IL)-1 beta, and expression of vPOPs causes activation of NF-kappa B. [Description provided by NIOSH]
• Subjects:
  Cells, Cultured Genetics Immune System Occupational Health Safety Viral Diseases
• Keywords:
  Cell-biology Cell-cultures Cell-metabolism Cellular-reactions Immune-system Immune-system-disorders Immunologic-disorders Viral-diseases Viral-infections
• ISSN:
  0920-8569
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  3
• NIOSHTIC Number:
  nn:20033020
• Citation:
  Virus Genes 2007 Dec; 35(3):685-694
• Contact Point Address:
  Christian Stehlik, Mary Babb Randolph Cancer Center and Department of Microbiology, Immunology & Cell Biology, West Virginia University School of Medicine, 1826 MBRCC, 1 Medical Center Drive, Morgantown, WV 26506-9300
• Email:
  cstehlik@hsc.wvu.edu
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Virus Genes
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:bd62df60a8a3a38587f12e5ea478c38be795febe167c1763db8920be013002713f5da17a0726453b3607c63a95b8505d4d88945669a9a44d110d34ce44d35829
• Download URL:
  https://stacks.cdc.gov/view/cdc/188755/cdc_188755_DS1.pdf
• File Type:
  [PDF - 461.50 KB ]