Excessive Longitudinal FEV1 Decline and Long-Term Health: A Case-Control Study

Details

• Personal Author:
  Avashia B ; Petsonk, Edward L. ; Wang, Mei Lin
• Description:
  Rationale: Spirometry is often performed annually to monitor lung health. Excessive FEV, loss in an individual is considered a useful indicator of the development of lung disease. Methods: Using medical monitoring data collected between 1973 and 2003 at a large chemical plant, longitudinal FEV, slopes (ml/yr) were calculated by simple linear regression for all workers (N = 1428) with > or = 5 valid measurements over > or = 10 years. Cases were defined by FEY, slopes below 5th percentile values (-65, -56 ml/yr for white and black males, and -50 ml/yr for white females). Cases (N=64) were matched with controls (N=94, FEV, slope range = -46 to 26 ml/yr) for race, gender, smoking status, year of birth, age, height, and calendar year of first test. Health information on medication use, respiratory symptoms and signs, and lung disease diagnoses was abstracted from existing plant medical records for the 4 years prior to the last spirometry. The significance of differences in frequencies of health outcomes was tested using matched paired chi square tests (McNemar's Test or Exact McNemar's Test). Results: Cases had a higher proportion of several respiratory health outcomes compared to controls, including medication use for respiratory diseases (24.3% vs. 4.7%, p<0.0001), diagnosis of COPD or emphysema (17.8% vs. 1.9%, p=0.0002), dyspnea (15% vs. 3.7%, p=0.0042), and wheezing or rhonchi on examination (10.3% vs. 1.9%, p=0.0225). Conclusions: This study expands the scientific basis for monitoring respiratory health using spirometry, by providing quantitative estimates of the increase in respiratory disorders (from 4 to 9 times) among individuals with accelerated FEY, declines. [Description provided by NIOSH]
• Subjects:
  Demography Lung Manufacturing And Industrial Facilities Men Occupational Health Respiratory Function Tests Respiratory System Safety Women
• Keywords:
  Chemical-factory-workers Chemical-industry-workers Demographic-characteristics Humans Lung-function Pulmonary-function Pulmonary-function-tests Respiratory-function-tests Spirometry Statistical-analysis Surveillance

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• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  175
• NIOSHTIC Number:
  nn:20032978
• Citation:
  Am J Respir Crit Care Med 2007 Apr; 175(Abstracts):A430
• Email:
  MLW4@CDC.GOV
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstracts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e349c360adb0bad3963722895416889beecf5af65d7e58f0a03266888a33a6b442dd4a7d7417638e62d06f77e4c47bf9378f6f1f884e521c24ff4d8bf1108f58
• Download URL:
  https://stacks.cdc.gov/view/cdc/188724/cdc_188724_DS1.pdf
• File Type:
  [PDF - 512.68 KB ]