Contralateral Prophylactic Mastectomy for Patients with Unilateral Breast Cancer

Details

• Personal Author:
  Abraham A ; Emory T ; Habermann E ; Tuttle T ; Virnig B
• Description:
  Patients with unilateral breast cancer are at increased risk of developing a second cancer in the contralateral breast. Some women choose contralateral prophylactic mastectomy (CPM) to prevent cancer in the contralateral breast. Several studies have demonstrated that CPM significantly decreases the occurrence of contralateral breast cancer. However, the effectiveness of CPM at reducing breast cancer mortality is not as clear. Moreover, CPM is not risk free and patients may need to undergo additional surgical procedures, especially if reconstruction is performed. Nevertheless, most patients are satisfied with their decision to undergo CPM. Alternatives to CPM include close surveillance with clinical breast examination, mammography and possibly breast magnetic resonance imaging. Endocrine therapy with tamoxifen or aromatase inhibitors significantly reduces the risk of contralateral breast cancer and may be more acceptable than CPM for some patients. The decision to undergo CPM is complex and many factors likely contribute to its use. Future prospective studies are critically needed to evaluate the decision-making processes leading to CPM. [Description provided by NIOSH]
• Subjects:
  Environmental Monitoring Epidemiology Family Genetics Neoplasms Occupational Health Preventive Medicine Risk Assessment Risk Factors Safety Urogenital Diseases

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• Keywords:
  Biological-effects Biological-systems Breast-cancer Cancer-rates Exposure-assessment Exposure-levels Exposure-methods Families Genetic-factors Mammary-glands Medical-screening Medical-treatment Preventive-medicine Prophylaxis Qualitative-analysis Reproductive-system-disorders Risk-analysis Risk-factors Statistical-analysis Surgery Treatment

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• ISSN:
  1473-7140
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  7
• Issue:
  8
• NIOSHTIC Number:
  nn:20037551
• Citation:
  Expert Rev Anticancer Ther 2007 Aug; 7(8):1117-1122
• Contact Point Address:
  Todd Tuttle, University of Minnesota, Department of Surgery, Division of Surgical Oncology, 420 Delaware St SE, Minneapolis, MN
• Email:
  tuttl006@umn.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Expert Review of Anticancer Therapy
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6b709351ba242ab8735dde120e15a3d704988683312ffd1a8870fbbc3b6b925816e18d7b2acd5df0866a3bc8c90cd7ebc75bc0d448bfb9c469da788bd1e33a6b
• Download URL:
  https://stacks.cdc.gov/view/cdc/188628/cdc_188628_DS1.pdf
• File Type:
  [PDF - 236.04 KB ]