Talc Pneumoconiosis: Significance of Sublight Microscopic Mineral Particles

Details

• Personal Author:
  Bader ME ; Bader RA ; Miller, Aubrey K. ; Selikoff IJ ; Teirstein AS
• Description:
  Described herein is a patient with talc pneumoconiosis whose symptoms began fifteen years after heavy exposure and who progressed to massive fibrosis and death seven years later from cardiopulmonary insufficiency. Studies of pulmonary function showed restriction of lung volumes, loss of pulmonary compliance and increased venous admixture with moderate hypoxemia. Cardiac catheterization revealed pulmonary hypertension. Lung tissue was analyzed for mineral content by x-ray diffraction and electron microscopy, which established the presence of talc in the absence of histologic demonstration of mineral particles by conventional light microscopy. The significance of submicroscopic talc particles in the production of disease is demonstrated and related to similar findings in asbestosis. [Description provided by NIOSH]
• Subjects:
  Dust Occupational Health Particulate Matter Respiratory Tract Diseases Safety Talc
• Keywords:
  Dust-exposure Dust-inhalation Dust-particles Mineral-dusts Particulate-dust Pneumoconiosis Pulmonary-system-disorders Respirable-dust Respiratory-system-disorders Talc-dust
• ISSN:
  0002-9343
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  395-402
• Volume:
  50
• Issue:
  3
• NIOSHTIC Number:
  nn:20037411
• Citation:
  Am J Med 1971 Mar; 50(3):395-402
• Contact Point Address:
  Dr. Albert Miller, Pulmonary Function Laboratory, The Mount Sinai Hospital, 100th Street and Fifth Avenue, New York, New York 10029
• CAS Registry Number:
  Talc (Mg3H2(SiO3)4) (CAS RN 14807-96-6)
• Federal Fiscal Year:
  1971
• Performing Organization:
  Mount Sinai School of Medicine, New York, New York
• Peer Reviewed:
  True
• Start Date:
  19701201
• Source Full Name:
  The American Journal of Medicine
• End Date:
  19731130
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a3a8cc85b196822089a63499e05b14f6560e88e0f2134d872a2d84594bfd1198a7b6ce309f99ca662e4223e5cda5b5a60e11bec4394c7971827a1097b64dd124
• Download URL:
  https://stacks.cdc.gov/view/cdc/188509/cdc_188509_DS1.pdf
• File Type:
  [PDF - 1.33 MB ]