Asthma, Atopy, and Lung Function Among Racially Diverse, Poor Inner-Urban Minneapolis Schoolchildren

Details

• Personal Author:
  Adgate JL ; Blumenthal MN ; Church, Timothy R. ; Fredrickson AL ; Geisser MS ; Greaves IA ; Ramachandrana G ; Ryan, Andrew D. ; Sexton K
• Description:
  As part of an assessment of schoolchildren's environmental exposures and health, a probability sample of 136 children from diverse racial/ethnic backgrounds was drawn from grades 2-5 of two inner-urban Minneapolis schools (Whittier, Lyndale). Questionnaires were administered to a parent/guardian; blood samples for IgE and lung function tests were obtained. Overall adjusted rates for lifetime asthma (15.4%; 95%CI 9.3-21.5%), asthma in the last 12 months (13.6%; 7.8-19.4%), and current asthma medication use (10.5%; 5.3-15.7%) were higher than reported US national rates. Adjusted rates for lifetime physician-diagnosed asthma differed significantly among racial/ethnic groups (Po0.01): African-Americans (25.9%), White/Others (25.8%), Hispanics (9.3%), Somalis (1.8%), Asians (0%). Corresponding rates for atopy (total IgE4100 IU/mL or an allergen-specific IgE40.35 IU/mL) were: African-Americans (66.6%), White/Others (100%), Hispanics (77.2%), Somalis (78.1%), Asians (81.8%). Lung function (FEV1, FVC) was analyzed by linear regression using log-transformed data: significant race-specific differences in lung function were found relative to White/Others (Po0.001 for each racial/ethnic group): African-Americans (FEV1 -16.5%, FVC -16.9%), Somalis (-22.7%, -26.8%), Hispanics (-12.2%, -11.4%) and Asians (-11.1%, -12.4%). Females had significantly lower FEV1 (-8.8%) and FVC (-11.0%) than males. An unexplained, significant difference in children's lung function was found between the two schools. A history of physician-diagnosed asthma was not associated with decreased lung function. Factors other than poverty, inner-urban living, and IgE levels (atopy) need to be considered in the development of childhood asthma. [Description provided by NIOSH]
• Subjects:
  Asthma Asthma, Occupational Hypersensitivity Immune System Irritants Lung Lung Diseases Occupational Health Race Factors Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Allergic-reactions Allergies Atopy Author Keywords: Minority Children Home And School Environments Humans Immune-reaction Lung-function Lung Function Pulmonary-disorders Pulmonary-function Pulmonary-system-disorders Racial-factors Respiratory-hypersensitivity Respiratory-infections Respiratory-irritants Respiratory-system-disorders

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• ISSN:
  0013-9351
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Minnesota ; OSHA Region 5 ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  257-266
• Volume:
  103
• Issue:
  2
• NIOSHTIC Number:
  nn:20037387
• Citation:
  Environ Res 2007 Feb; 103(2):257-266
• Contact Point Address:
  Ian A. Greaves, Division of Environmental Health Sciences, School of Public Health, University of Minnesota, MMC 807, 420 Delaware Street. S.E., Minneapolis, MN 55455
• Email:
  igreaves@umn.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of Minnesota Twin Cities
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Research
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:837c0a04dc18110fe3f1d2147b3369e7c2cccf5481933b00644128c5c9189d11f37569baecb3ca1cf3241c58b5bf2d0c38f35fa04b3ab30271477d2a0d45f534
• Download URL:
  https://stacks.cdc.gov/view/cdc/188486/cdc_188486_DS1.pdf
• File Type:
  [PDF - 204.31 KB ]