Lamotrigine-Induced Seizures in a Child: Case Report and Literature Review

Details

• Personal Author:
  Anderson IB ; Olson KR ; Stewart PJ ; Thundiyil JG
• Description:
  INTRODUCTION: Lamotrigine is an antiepileptic agent. There is only one previous report of a seizure associated with lamotrigine overdose with laboratory confirmation (a 2-year-old girl, lamotrigine level of 3.8 mg/L). CASE REPORT: A healthy 19-month-old boy ingested an unknown amount of his sister's lamotrigine tablets. Twenty minutes later, the child experienced generalized seizure activity lasting 10 seconds, followed by another brief self-limited seizure. Vitals signs: heart rate 152-207 bpm crying, respiratory rate 26 /min, temperature 95.7 degrees F, and pupils 3mm. The one-hour lamotrigine level = 20.3 mg/L. The child was discharged 24 hours later. LITERATURE REVIEW: Six previous case reports of lamotrigine poisoning with serum levels, as well as a retrospective review of lamotrigine exposures, are discussed. CONCLUSION: A case of lamotrigine-induced seizures in a pediatric patient is reported, with a level approximately five times the upper limit of the therapeutic range. The pediatric population may be at increased risk of seizures following lamotrigine poisoning, and serum levels may not be clinically useful for predicting outcome after overdose. [Description provided by NIOSH]
• Subjects:
  Aging Emergency Responders Environmental Monitoring Hazardous Substances Health Care Facilities Workforce And Services Hypersensitivity Nervous System Occupational Health Poisoning Risk Assessment Risk Factors Safety

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• Keywords:
  Age-groups Author Keywords: Lamotrigine Biological-effects Chemical-hypersensitivity Children Drug-Interaction Drugs Emergency-care Emergency-treatment Exposure-assessment Exposure-levels Exposure-methods Health-hazards Medical-monitoring Medical-treatment Neurological-reactions Neurological-system Pediatric Physiological-effects Physiological-measurements Physiological-response Poison-control Poisons Risk-analysis Risk-factors Seizure Statistical-analysis

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• ISSN:
  1556-3650
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Florida ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  169-172
• Volume:
  45
• Issue:
  2
• NIOSHTIC Number:
  nn:20037246
• Citation:
  Clin Toxicol 2007 Mar; 45(2):169-172
• Contact Point Address:
  Josef G. Thundiyil, School of Medicine, University of California, San Francisco, UCSF box 1369, San Francisco, CA 94143-1369
• Email:
  joseft@mindspring.com
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Clinical Toxicology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:90175314b7105cc713db634c45cb7d3df0d14992a0a9e0f6d57d2e40bcb27ac2a7518386cf744a5a207926c017ad958e1b2f1b2d97fcf1e1f22e35c41952b837
• Download URL:
  https://stacks.cdc.gov/view/cdc/188365/cdc_188365_DS1.pdf
• File Type:
  [PDF - 73.08 KB ]