Arsenic Methylation and Bladder Cancer Risk in Case-Control Studies in Argentina and the United States

Details

• Personal Author:
  Atallah R ; Bates MN ; Biggs ML ; Hoang BK ; Hopenhayn C ; Kalman D ; Moore LE ; Rey OA ; Smith AH ; Steinmaus C ; Yuan Y
• Description:
  OBJECTIVE: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. METHODS: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). RESULTS: In Argentina, the adjusted odds ratio (OR) for subjects with a high proportion of ingested arsenic excreted as monomethylarsonate (%MMA) was 2.17 (95% confidence interval [CI] = 1.02-4.63) in smokers and 0.48 (95% CI = 0.17-1.33) in nonsmokers. In the United States, the adjusted ORs for high %MMA in subjects with arsenic intakes less than and greater than 100 microg/d were 1.20 (95% CI = 0.27-5.38) and 2.70 (95% CI = 0.39-18.6). CONCLUSIONS: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer. [Description provided by NIOSH]
• Subjects:
  Chemistry Demography Diet Drinking Water Environmental Monitoring Health Care Facilities Workforce And Services Hypersensitivity Occupational Health Risk Assessment Safety Smokers Urine

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• Keywords:
  Biological-effects Chemical-deposition Chemical-hypersensitivity Chemical-properties Demographic-characteristics Dietary-effects Drinking-water Exposure-assessment Exposure-levels Exposure-methods Medical-monitoring Physiological-effects Physiological-measurements Physiological-response Risk-analysis Smoking Statistical-analysis Urine-chemistry

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• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  478-488
• Volume:
  48
• Issue:
  5
• NIOSHTIC Number:
  nn:20037214
• Citation:
  J Occup Environ Med 2006 May; 48(5):478-488
• Contact Point Address:
  Allan H. Smith, Arsenic Health Effects Research Program, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720-7360
• Email:
  ahsmith@uclink.berkeley.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2006
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c9baab6afda7b381d024b48675dd2fa24372d1a036043519ede143c8c6597bd2f872b6ae59adabdb80527ac44a37b4e8d587199211499912137bbdffd7c4f92c
• Download URL:
  https://stacks.cdc.gov/view/cdc/188343/cdc_188343_DS1.pdf
• File Type:
  [PDF - 241.01 KB ]