Quality of Life for Men Receiving a Second Treatment for Prostate Cancer

Details

• Personal Author:
  Arredondo SA ; Carroll PR ; DuChane J ; Kawakami J ; Latini DM ; Pasta DJ ; Sadetsky N
• Corporate Authors:
  University of California, San Francisco. Cancer of the Prostate Strategic Urologic Research Endeavor
• Description:
  Purpose: We assessed the impact of second treatment on health related quality of life for men with prostate cancer. This issue is important because second treatment resulting from prostate specific antigen recurrence has the potential to further negatively impact health related quality of life and affect the overall value of treatment. We compared differences in health related quality of life before and after second treatment for men who had asymptomatic prostate specific antigen recurrence with those who did not have biochemical failure. Materials and Methods: Men in this analysis (897) had localized disease, initially underwent radical prostatectomy monotherapy, and completed at least 1 health related quality of life questionnaire before and after radical prostatectomy. In this cohort 175 men underwent second treatment (nonadjuvant). The Medical Outcomes Survey Short Form-36 and UCLA Prostate Cancer Index were used to measure health related quality of life. Associations between patient groups and time on health related quality of life were analyzed using repeated measures. Results: Men who received a second treatment presented with more severe disease before radical prostatectomy and had worse general health related quality of life. Although health related quality of life differed significantly with time for the 2 groups, most domains for the second treatment group improved or remained stable until 15 months before second treatment, at which point they declined. Scores in the sexual functioning and role-physical domains showed clinically and statistically significant patterns of decreasing with time. Conclusions: Health related quality of life is affected following second treatment but starts to decline approximately 1 year before second treatment. Not all aspects of health related quality of life decreased at the same rate, so patients should be counseled that certain domains may be affected more by additional treatment. [Description provided by NIOSH]
• Subjects:
  Health Care Facilities Workforce And Services Men Neoplasms Occupational Health Quality Control Safety Surveys And Questionnaires Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: Quality Of Life Biological-effects Medical-monitoring Medical-surveys Medical-treatment Outcome Assessment Physiological-effects Physiological-measurements Physiological-response Prostate-cancer Prostatic Neoplasms Qualitative-analysis Quality-standards Questionnaires Statistical-analysis Surgery

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• ISSN:
  0022-5347
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Illinois ; OSHA Region 5 ; OSHA Region 6 ; OSHA Region 9 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  273-278
• Volume:
  177
• Issue:
  1
• NIOSHTIC Number:
  nn:20037208
• Citation:
  J Urol 2007 Jan; 177(1):273-278
• Contact Point Address:
  David M. Latini, Houston Center for Quality of Care & Utilization Studies, Michael E. DeBakey Veterans Affairs Medical Center (152), 2002 Holcombe Blvd., Houston, Texas 77030
• Email:
  latini@bcm.tmc.edu
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  The Journal of Urology
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ae735da58be0b21ed6eb4857e0b79d022821c0ae1ac9dd04c82df4be2fb8bd62394ca132433ff94af3a89443dca1b0432a2f9a6ca672931e05a856c5a7436bc
• Download URL:
  https://stacks.cdc.gov/view/cdc/188338/cdc_188338_DS1.pdf
• File Type:
  [PDF - 103.97 KB ]