Association Between IL-1A Single Nucleotide Polymorphisms and Chronic Beryllium Disease and Beryllium Sensitization

Details

• Personal Author:
  Andrew M ; Frye BL ; Kreiss, Kathleen ; McCanlies EC ; Mnatsakanova A ; Schuler, Christine R. ; Slaven E ; Weston A ; Yucesoy, Berran ; Andrew M ; Frye BL ; Kreiss, Kathleen ; McCanlies EC ; Mnatsakanova A ; Schuler, Christine R. ; Slaven E ; Weston A ; Yucesoy, Berran
• Description:
  Objective: To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS). Methods: Forty SNPs in six IL genes were evaluated in 85 individuals with CBD, 61 individuals with BeS, and 730 individuals without BeS or CBD (nonsensitized) using a 5' nuclease polymerase chain reaction assay. Logistic regression was used to evaluate the association between IL SNPs, CBD, and BeS, adjusting for plant-site and HLA-DPB1(Glu69) in additive, dominant, and recessive inheritance models. Results: IL-1A-1142, IL-1A-3769, and IL-1A-4697 were significantly associated with CBD in both the additive and dominant models compared to individuals with BeS or the nonsensitized. Conclusions: These results indicate that genetic variations in the IL-1A gene may play a role in the development of CBD but not BeS. [Description provided by NIOSH]
• Subjects:
  Biochemistry Biological Factors Chemistry Environmental Monitoring Genetics Hazardous Substances Hypersensitivity Occupational Health Safety
• Keywords:
  Biochemical-analysis Biohazards Biological-effects Biological-factors Cell-alteration Cell-biology Cell-morphology Cellular-reactions Chemical-hypersensitivity Chemical-reactions Chemical-synthesis Exposure-assessment Exposure-levels Genes Genetic-factors

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• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies ; HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  52
• Issue:
  7
• NIOSHTIC Number:
  nn:20037170
• Citation:
  J Occup Environ Med 2010 Jul; 52(7):680-684
• Contact Point Address:
  Erin McCanlies, PhD, National Institute for Occupational Safety and Health (NIOSH), Centers for Disease Control and Prevention (CDC), Health Effects Laboratory Division, MS-L4050, 1095 Willowdale Road, MS2027, Morgantown, WV 26505
• Email:
  eim4@cdc.gov
• CAS Registry Number:
  Beryllium (CAS RN 7440-41-7) ; Beryllium (CAS RN 7440-41-7)
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4c8b19749cc49468bb299bd89bd3f0a60d2c2d305725ae3036124e8af034979293f9069c00abd42ca3f95ad74d6523a0b5d850e494dd20398adef3182eed58b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/188303/cdc_188303_DS1.pdf
• File Type:
  [PDF - 127.32 KB ]