Temporal Characteristics of Aerosol Generation During a Voluntary Cough

Details

• Personal Author:
  Afshari AA ; Day JB ; Frazer DG ; Goldsmith WT ; Jones BM ; Afshari AA ; Day JB ; Frazer DG ; Goldsmith WT ; Jones BM
• Description:
  RATIONALE: Infectious diseases can be spread by the generation and airborne transmission of particles containing bacteria and viruses. The objective of this study was to explore the time course of aerosol generation during a voluntary cough. METHODS: A system was designed in which subjects (N=9) voluntarily coughed through a cylindrical mouthpiece into a straight tube (228.5cm x 5 cm dia.) attached to a spirometer. The tube was divided into 4 sections. The first three sections were 70 cm in length, and the fourth was 15.25 cm in length and included the spirometer. The tube and spirometer were held at 37oC to minimize condensation effects. Prior to a subject coughing into the system, the tube and spirometer were washed out with HEPA filtered air. Following a voluntary cough, valves separating each tube section were closed. The particle size distribution of the expelled aerosol was then simultaneously measured within each section using 4 light scattering particle sizers. The spirometer was used to record cough airflow and gas volume. RESULTS: As the volume of the cough increased, the cumulative count distributions were shifted further down the tube. Cumulative count percentages in the first section of the tube (those particles expelled last during the cough) decreased when the initial portion of the cough volume moved further from the mouth. CONCLUSIONS: Based on particle count and particulate mass data for each subject, the majority of the aerosol was produced during the initial expulsive portion of a cough. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Pollutants, Occupational Communicable Diseases Dust Environmental Monitoring Irritants Laboratories Lung Occupational Health Particulate Matter Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Respiratory Tract Diseases Risk Assessment Safety

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• Keywords:
  Aerosol-particles Airborne-dusts Airborne-particles Airborne Transmission Analytical-methods Author Keywords: Cough Analysis Bioaerosols Biological-effects Biological-monitoring Exposure-assessment Exposure-levels Exposure-methods Infectious-diseases Inhalation-studies Laboratory-techniques Lung-irritants Particle-aerodynamics Particle-counters Particulate-sampling-methods Pulmonary-system Respiratory-hypersensitivity Respiratory-irritants Respiratory-system-disorders Risk-analysis Spirometry Statistical-analysis Voluntary Cough

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• ISSN:
  1073-449X
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  181
• NIOSHTIC Number:
  nn:20037135
• Citation:
  Am J Respir Crit Care Med 2010 May; 181(Meeting Abstracts):A2183
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing ; Manufacturing
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Meeting Abstracts
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ec4409c3fd70ee4c3904840f8b8c57e2c822dc2a502995e2a7fd63abe5aae6810f596b0b3759b1046a6fe6f76aabd5d1d4996b19e6934da924d0ff23a9f342f
• Download URL:
  https://stacks.cdc.gov/view/cdc/188284/cdc_188284_DS1.pdf
• File Type:
  [PDF - 16.72 KB ]