Research Recommendations for Selected IARC-Classified Agents

Details

• Personal Author:
  Caldwell JC ; Carreón T ; Cogliano VJ ; Demarini DM ; Fowler BA ; Goldstein BD ; Hemminki K ; Hines CJ ; Hoar Zahm S ; Hopf NB ; Husgafvel-Pursiainen K ; Kuempel, Eileen D. ; Lewtas J ; Lunn RM ; Lynge E ; McElvenny DM ; Muhle H ; Nakajima T ; Robertson LW ; Rothman N ; Ruder, Avima M. ; Schubauer-Berigan, Mary K. ; Schulte, Paul A. ; Siemiatycki J ; Silverman D ; Smith MT ; Sorahan T ; Steenland, Kyle ; Stevens RG ; Straif K ; Vineis P ; Ward, Elizabeth M. ; Zeise L ; Caldwell JC ; Carreón T ; Cogliano VJ ; Demarini DM ; Fowler BA ; Goldstein BD ; Hemminki K ; Hines CJ ; Hoar Zahm S ; Hopf NB ; Husgafvel-Pursiainen K ; Kuempel, Eileen D. ; Lewtas J ; Lunn RM ; Lynge E ; McElvenny DM ; Muhle H ; Nakajima T ; Robertson LW ; Rothman N ; Ruder, Avima M. ; Schubauer-Berigan, Mary K. ; Schulte, Paul A. ; Siemiatycki J ; Silverman D ; Smith MT ; Sorahan T ; Steenland, Kyle ; Stevens RG ; Straif K ; Vineis P ; Ward, Elizabeth M. ; Zeise L
• Description:
  OBJECTIVES: There are some common occupational agents and exposure circumstances where evidence of carcinogenicity is substantial but not yet conclusive for humans. The objectives are to identify research gaps and needs for twenty agents prioritized for review based on evidence of widespread human exposures and potential carcinogenicity in animals or humans. DATA SOURCES: A systematic review was conducted of new data published since the most recent pertinent IARC monograph meeting. DATA EXTRACTION: Reviewers were charged with identifying data gaps and general and specific approaches to address them, focusing on research that would be important in resolving classification uncertainties. An expert meeting brought reviewers together to discuss each agent and the identified data gaps and approaches. DATA SYNTHESIS: Several overarching issues were identified that pertained to multiple agents; these included the importance of recognizing that carcinogenic agents can act through multiple toxicity pathways and mechanisms, including epigenetic mechanisms, oxidative stress and immuno- and hormonal modulation. CONCLUSIONS: Studies in occupational populations provide important opportunities to understand the mechanisms through which exogenous agents cause cancer and intervene to prevent human exposure and/or prevent or detect cancer among those already exposed. Scientific developments are likely to increase the challenges and complexities of carcinogen testing and evaluation in the future, and epidemiologic studies will be particularly critical to inform carcinogen classification and risk assessment processes. [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Epidemiology Laboratories Occupational Health Safety
• Keywords:
  Animal-studies Author Keywords: Animal Carcinogen Carcinogenesis Carcinogenicity Human IARC Laboratory-animals Mechanisms Of Carcingenicity Occupational Statistical-analysis

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• ISSN:
  0091-6765
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  California ; Connecticut ; Georgia ; Iowa ; Maryland ; North Carolina ; Ohio ; OSHA Region 1 ; OSHA Region 10 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5 ; OSHA Region 7 ; OSHA Region 9 ; Pennsylvania ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Volume:
  118
• Issue:
  10
• NIOSHTIC Number:
  nn:20036985
• Citation:
  Environ Health Perspect 2010 Oct; 118(10):1355-1362
• Contact Point Address:
  Elizabeth M. Ward PhD., Epidemiology and Surveillance Research, American Cancer Society, 250 Williams Street, Atlanta, GA 30303-1002, USA
• Email:
  elizabeth.ward@cancer.org
• Federal Fiscal Year:
  2011
• NORA Priority Area:
  Agriculture, Forestry and Fishing ; Manufacturing ; Agriculture, Forestry and Fishing ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Environmental Health Perspectives
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:739b0e0c3941b2a18811fd27d87b96de2c36d4035cb782cac16f4000ac74c700ab7e2136ed3a066f69a3c0aa6c1f5577dc87c0a377354fa24276b847ff915776
• Download URL:
  https://stacks.cdc.gov/view/cdc/188172/cdc_188172_DS1.pdf
• File Type:
  [PDF - 207.18 KB ]