Intrauterine Tobacco Exposure May Alter Auditory Brainstem Responses in Newborns

Details

• Personal Author:
  Beebe L ; Neas B ; Peck JD ; Robledo C ; Saffer E ; Wild RA
• Description:
  This study of tobacco exposure and auditory processes was conducted in a predominantly low-income population of 40 pregnant women and their newborns. Urinary cotinine concentrations and self-reported smoking status were obtained from the mother during the first prenatal care visit. Auditory brainstem-evoked responses (ABRs) were recorded in neonates to assess neuroelectrical activity of the auditory nerve following a sound stimulus. Infants of mothers with the highest cotinine concentrations (> 1,000 ng/ml) responded at a rate that was four times greater (hazard ratio 4.1, 95% confidence interval 1.4-11.5) than infants of non-smoking mothers (cotinine 15-1,000 ng/ml) were not observed. Enhanced ABRs may disrupt auditory processes related to speech perception, negatively affecting reading and language development during childhood. The results suggest that tobacco exposure during pregnancy may impair auditory function. [Description provided by NIOSH]
• Subjects:
  Nervous System Occupational Health Risk Assessment Safety Tobacco Products
• Keywords:
  Auditory-system Auditory Brainstem Response Author Keywords: Tobacco Biological-effects Cotinine Exposure-assessment Exposure-levels Exposure-methods Neurological-reactions Newborn Prenatal-exposure Risk-analysis Smoking Statistical-analysis Tobacco-constituents

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• ISSN:
  0001-6349
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Oklahoma ; OSHA Region 6 ; Texas
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  89
• Issue:
  4
• NIOSHTIC Number:
  nn:20036700
• Citation:
  Acta Obstet Gynecol Scand 2010 Apr; 89(4):592-596
• Contact Point Address:
  Jennifer David Peck, Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104
• Email:
  jennifer-peck@ouhsc.edu
• Federal Fiscal Year:
  2010
• Performing Organization:
  University of Texas Health Science Center, Houston
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Acta Obstetricia et Gynecologica Scandinavica
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6e837e77ceaeb19148b1e26b538273071ff87b301d3793d08269447f3983dc299c84f22ae74d4b59df56e00e005720e0c4cdc32c6e83062806ad77c0ee7d32d6
• Download URL:
  https://stacks.cdc.gov/view/cdc/188020/cdc_188020_DS1.pdf
• File Type:
  [PDF - 94.38 KB ]