Multiple Myeloma in World Trade Center Responders: A Case Series

Details

• Personal Author:
  Crowley L ; Herbert R ; Hodgman E ; Landrigan, Philip J. ; Luft B ; Moline JM ; Savitz DA ; Shukla G ; Troy K ; Udasin I ; Wallenstein S
• Description:
  OBJECTIVES: We report on cases of multiple myeloma (MM) observed in World Trade Center (WTC) responders registered in the WTC Medical Program. METHODS: Possible cases of MM diagnosed between September 11, 2001, and September 10, 2007, in responders were confirmed if they met the World Health Organization and Mayo Clinic diagnostic criteria. RESULTS: Among 28,252 responders of known sex and age, eight cases of MM were observed (6.8 expected). Four of these cases were observed in responders younger than 45 years at the time of diagnosis (1.2 expected). A slight deficit of MM cases was observed in responders older than 45 years (4 observed, 5.6 expected). CONCLUSION: In this case series, we observe an unusual number of MM cases in WTC responders under 45 years. This finding underscores the importance of maintaining surveillance for cancer and other emerging diseases in this highly exposed population. [Description provided by NIOSH]
• Subjects:
  Aging Blood Carcinogens Neoplasms Occupational Health Safety
• Keywords:
  Age-groups Blood-cells Cancer Disease-incidence Statistical-analysis Surveillance-programs Tumorigenesis Tumorigens
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Contract ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; New Jersey ; New York ; OSHA Region 2 ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  51
• Issue:
  8
• NIOSHTIC Number:
  nn:20036246
• Citation:
  J Occup Environ Med 2009 Aug; 51(8):896-902
• Contact Point Address:
  Jacqueline Moline, MD, MSc, Department of Community and Preventive Medicine, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, Box 1057, New York, NY 10029
• Email:
  jacqueline.moline@mssm.edu
• Federal Fiscal Year:
  2009
• Performing Organization:
  Mount Sinai School of Medicine - New York
• Peer Reviewed:
  True
• Start Date:
  20040601
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20100531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8ae4fb8784116a41b183048bf88a574831856e9d19e4bf3a146c629f4d4e9645b5b175b038b89f07835a27b5f4b29a48aa93936284c9a791d858fbffed110c96
• Download URL:
  https://stacks.cdc.gov/view/cdc/187738/cdc_187738_DS1.pdf
• File Type:
  [PDF - 177.43 KB ]