Incorporating Genetics and Genomics in Risk Assessment for Inhaled Manganese: From Data to Policy

Details

• Personal Author:
  Curran CP ; Haynes EN ; Ho SM ; Park RM
• Description:
  Manganese is an essential nutrient, and a healthy human with good liver and kidney function can easily excrete excess dietary manganese. Inhaled manganese is a greater concern, because it bypasses the body's normal homeostatic mechanisms and can accumulate in the brain. Prolonged exposure to high manganese concentrations (>1 mg/m(3)) in air leads to a Parkinsonian syndrome known as "manganism." Of greatest concern are recent studies which indicate that neurological and neurobehavioral deficits can occur when workers are exposed to much lower levels (<0.2 mg/m(3)) of inhaled manganese in welding fumes. Consequently, researchers at NIOSH are conducting a risk assessment for inhaled manganese. Novel components of this risk assessment include an attempt to quantify the range of inter-individual differences using data generated by the Human Genome Project and experimental work to identify genetically based biomarkers of exposure, disease and susceptibility. The difficulties involved in moving from epidemiological and in vivo data to health-based quantitative risk assessment and ultimately enforceable government standards are discussed. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Biochemistry Biomarkers Environmental Monitoring Epidemiology Hypersensitivity Nervous System Nervous System Disorders Occupational Health Particulate Matter Respiratory System Safety

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• Keywords:
  Airborne-particles Author Keywords: Manganese Biological-monitoring Central-nervous-system-disorders Chemical-hypersensitivity DNA Exposure-assessment Exposure-levels Exposure-methods Genetic Susceptibility Genotoxic-effects Inhalation-studies Neurological-reactions Neurological-system Neurotoxic-effects Neurotoxicology Occupational Health Policy Quantitative-analysis

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• ISSN:
  0161-813X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Kentucky ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  30
• Issue:
  5
• NIOSHTIC Number:
  nn:20036084
• Citation:
  Neurotoxicology 2009 Sep; 30(5):754-760
• Contact Point Address:
  Christine P. Curran, Department of Biological Sciences, Northern Kentucky University, SC342 Nunn Drive, Highland Heights, KY 41099
• Email:
  curranc1@nku.edu
• CAS Registry Number:
  Magnesium (CAS RN 7439-95-4)
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Construction
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:716069437529be4daaa33785a64af7915268cd118e6b851595bcdae32bfd5e81eada1c87d29c5ec6c539032b1336b12e173562ae7c4bc8e0f7d2094b397b480a
• Download URL:
  https://stacks.cdc.gov/view/cdc/187677/cdc_187677_DS1.pdf
• File Type:
  [PDF - 205.00 KB ]