Increased Bladder Cancer Risk Among Workers Exposed to O-Toluidine and Aniline: A Reanalysis

Details

• Personal Author:
  Carreón T ; Hanley, Kevin W. ; Hein, Misty J. ; Ruder, Avima M. ; Viet SM ; Ward, Elizabeth M.
• Description:
  Introduction: In 1991, the U.S. National Institute for Occupational Safety and Health (NIOSH) reported an increased bladder cancer risk in a cohort of 1749 workers potentially exposed to o-toluidine and aniline at a chemical manufacturing plant. Additional information showed that workers in certain departments had been misclassified regarding o-toluidine exposure; therefore, we conducted a reanalysis of the data using updated exposure categories. Methods: We updated exposure categories based on information ascertained during a plant walkthrough, documents on file at the plant, interviews with current and former employees, and answers provided by company and union officials on specific questions. Bladder cancer incidence was determined through 31 December 1988 and mortality through 31 December 1994. Results: Thirteen cases of bladder cancer were observed, versus 3.57 expected (New York State rates excluding New York City) [standardized incidence ratio (SIR) 3.64, 95% confidence interval (CI) 1.94-6.23]. Among workers classified as definitely exposed, increasing risks were observed for longer duration of employment [for .10 years, standardized rate ratio (SRR) 6.07, 95% CI 0.77-48.17] and time since first employment in the exposed departments (for .20 years, SRR 3.39, 95% CI 0.40-29.03). One bladder cancer death was observed among those definitely exposed. Conclusions: These findings are comparable to the results reported earlier by NIOSH, and confirm that workers in this plant have an increased risk of bladder cancer. [Description provided by NIOSH]
• Subjects:
  Manufacturing And Industrial Facilities Mortality Neoplasms Occupational Diseases Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System Workplace

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• Keywords:
  Author Keywords: O-toluidine Bladder-cancer Bladder-disorders Bladder Cancer Chemical-factory-workers Chemical-industry-workers Chemical-manufacturing-industry Chemical Industry Mortality-data NIOSH Occupational-diseases Occupational-exposure Occupational Exposure Risk-analysis Risk-factors Statistical-analysis Work-environment Work-performance Work-practices Worker-health Workplace-studies

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• ISSN:
  1351-0711
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  348-350
• Volume:
  66
• Issue:
  5
• NIOSHTIC Number:
  nn:20036082
• Citation:
  Occup Environ Med 2010 May; 66(5):348-350
• Contact Point Address:
  Tania Carreón, National Institute for Occupational Safety and Health, DSHEFS, Mail Stop R15, 4676 Columbia Parkway, Cincinnati, OH 45226
• Email:
  tjc5@cdc.gov
• CAS Registry Number:
  Aniline (CAS RN 62-53-3)
• Federal Fiscal Year:
  2010
• Peer Reviewed:
  True
• Source Full Name:
  Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dedc80c923a174c9bf498471331224ffa144a898e8a29d40186442bc9a5c85e161f41e628fa14399fcd5b137f8a1e1588f6cd637bd0bf81e6c16f534cbca022a
• Download URL:
  https://stacks.cdc.gov/view/cdc/187675/cdc_187675_DS1.pdf
• File Type:
  [PDF - 64.02 KB ]