High Dietary Antioxidant Intakes Are Associated with Decreased Chromosome Translocation Frequency in Airline Pilots

Details

• Personal Author:
  Petersen, Martin R. ; Sampson LA ; Sigurdson AJ ; Ward, Elizabeth M. ; Yong LC
• Description:
  Background: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. Objective: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. Design: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. Results: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios ( 95% CI) for >= median compared with, = median compared with, median combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55). Conclusion: High combined intakes of vitamins C and E, beta- carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons. [Description provided by NIOSH]
• Subjects:
  Aircraft Biomarkers Environmental Monitoring Occupational Exposure Occupational Health Risk Assessment Risk Factors Safety Surveys And Questionnaires
• Keywords:
  Aircrews Biological-function Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Mathematical-models Occupational-exposure Pilots Questionnaires Risk-factors Statistical-analysis Vitamins

  More +
• ISSN:
  0002-9165
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  90
• Issue:
  5
• NIOSHTIC Number:
  nn:20036041
• Citation:
  Am J Clin Nutr 2009 Nov; 90(5):1402-1410
• Contact Point Address:
  Lee C Yong, Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, R-15, Cincinnati, OH 45226
• Email:
  lay7@cdc.gov
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Transportation, Warehousing and Utilities
• Peer Reviewed:
  True
• Source Full Name:
  The American Journal of Clinical Nutrition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:96fba721b87d69eeac4b89ea509550e8635571820f9e064934baae4c170a050ee7aa11506b29c8be96b4070151ba2fd2247f8eb03bafb3474f7a1e2feed428c3
• Download URL:
  https://stacks.cdc.gov/view/cdc/187649/cdc_187649_DS1.pdf
• File Type:
  [PDF - 126.01 KB ]