JNK1, a Potential Therapeutic Target for Hepatocellular Carcinoma

Details

• Personal Author:
  Beezhold K ; Castranova, Vincent ; Chen F
• Description:
  Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite tremendous efforts to diagnose and institute new treatment regimens, the prognosis is still extremely poor. Therefore, knowledge of the molecular mechanisms governing the initiation, maintenance and progression of HCC is urgently needed. Recently, several groups have attributed an important role for c-Jun N-terminal kinase 1 (JNK1) in the pathogenesis of human HCC and its close association with the expression of HCC signature genes. In this review the various associations between JNK1 and HCC are discussed with the hope that targeting this pivotal kinase may lead to novel therapeutic approaches for this fatal disease. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biomarkers Cytotoxins Genetics Liver Neoplasms Occupational Health Safety
• Keywords:
  Author Keywords: JNK1 Biological-factors Cell-biology Cellular-reactions Cytotoxic-effects Cytotoxicity Epigenetics Genes Genetic-factors HCC Hepatocytes Liver-cancer Liver-disorders Molecular-biology Molecular-structure Pathogenesis Pathogenicity Pathogens Progenitor Cells ROS Signature Genes

  More +
• ISSN:
  0005-2728
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  242-251
• Volume:
  1796
• Issue:
  2
• NIOSHTIC Number:
  nn:20035908
• Citation:
  Biochim Biophys Acta Bioenerg 2009 Dec; 1796(2):242-251
• Contact Point Address:
  Fei Chen, Laboratory of Cancer Signaling and Epigenetics, Health Effects Laboratory Division, Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505
• Email:
  lfd3@cdc.gov
• Federal Fiscal Year:
  2010
• NORA Priority Area:
  Manufacturing ; Mining
• Peer Reviewed:
  True
• Source Full Name:
  Biochimica et Biophysica Acta - Bioenergetics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:58bfbce86cf4bc19673c956e52c78d4061d058ac0b503e010490c0632bdd622c183bcc73666830c0b6d39df76dd3d9a65f6a56152680c508a8f376edc5ab8aab
• Download URL:
  https://stacks.cdc.gov/view/cdc/187581/cdc_187581_DS1.pdf
• File Type:
  [PDF - 408.05 KB ]