Serum Cholinesterase Inhibition in Relation to Paraoxonase-1 (PON1) Status Among Organophosphate-Exposed Agricultural Pesticide Handlers

Details

• Personal Author:
  Checkoway, Harvey ; DeRoos AJ ; Farin FM ; Fenske RA ; Furlong CE ; Hofmann JN ; Keifer MC ; vanBelle G
• Description:
  BACKGROUND: Animal studies have demonstrated that low paraoxonase-1 (PON1) status (i.e., low catalytic efficiency and/or low plasma PON1 activity) is associated with neurotoxic effects after exposure to several organophosphate (OP) insecticides. However, few human studies have investigated associations between PON1 status and intermediate end points, such as serum cholinesterase [butyrylcholinesterase (BuChE)] inhibition, among OP-exposed individuals. OBJECTIVES: We evaluated the relation between plasma PON1 status and BuChE inhibition among OP-exposed agricultural pesticide handlers. METHODS: Agricultural pesticide handlers in Washington State were recruited during the 2006 and 2007 spray seasons when they were seen for follow-up ChE testing by collaborating medical providers as part of a statewide monitoring program. Blood samples were collected from 163 participants and tested for PON1 status based on plasma PON1 activity [arylesterase (AREase)] and PON1 Q192R genotype. We evaluated percent change in BuChE activity from baseline level in relation to PON1 status. RESULTS: We observed significantly greater BuChE inhibition among QQ homozygotes relative to RR homozygotes (p = 0.036). Lower levels of plasma PON1 activity were significantly associated with greater BuChE inhibition (p = 0.004). These associations remained after adjustment for year, days since baseline test, age, and OP exposure in the last 30 days. CONCLUSIONS: We found that both low PON1 catalytic efficiency (i.e., the Q192 alloform) and low plasma PON1 activity were associated with BuChE inhibition among OP-exposed agricultural pesticide handlers. Corroborative findings from future studies with prospective collection of blood samples for PON1 testing, more sensitive markers of OP-related effects, and larger sample sizes are needed. [Description provided by NIOSH]
• Subjects:
  Agriculture Biochemistry Hematologic Tests Hypersensitivity Insecticides Occupational Exposure Occupational Health Safety
• Keywords:
  Agricultural-industry Author Keywords: Agriculture Biochemical-analysis Biological-monitoring Blood-analysis Chemical-hypersensitivity Cholinesterase Exposure-methods Farmworkers Gene-environment Interaction' Organophosphates' Paraoxonase Occupational-exposure Pesticides Pesticides-and-agricultural-chemicals

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• ISSN:
  0091-6765
• Document Type:
  Text
• Funding:
  Grant ; Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 10 ; OSHA Region 3 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  117
• Issue:
  9
• NIOSHTIC Number:
  nn:20035897
• Citation:
  Environ Health Perspect 2009 Sep; 117(9):1402-1408
• Contact Point Address:
  J.N. Hofmann, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., EPS 8109, MSC 7240, Bethesda, MD 20892-724
• Email:
  hofmannjn@mail.nih.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Agriculture, Forestry and Fishing
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Environmental Health Perspectives
• End Date:
  20250630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:06d930a5cf0988b517e041fd34c62991044adb9f2a3c2ee555f1d4f1eae3704da9612cc9e745422b1f43e54bd14341524d748fa35472d6c73154e7e3942d4cec
• Download URL:
  https://stacks.cdc.gov/view/cdc/187575/cdc_187575_DS1.pdf
• File Type:
  [PDF - 262.15 KB ]