Incorporating Biomarkers into Cancer-Epidemiology – a Matrix of Biomarker and Study Design Categories

Details

• Personal Author:
  Rothman N ; Schulte, Paul A. ; Stewart WF
• Description:
  During the last decade, there has been increasing interest in the use of biomarkers in cancer epidemiology to enhance exposure assessment, to gain insight into disease mechanism, and to understand acquired or inherited susceptibility. To facilitate the use of biomarkers in health research, biomarkers have been divided into categories that depict the spectrum of cancer pathogenesis from exposure to disease. In this paper, we consider the epidemiological designs most suitable for the study of each type of marker. In particular, we present a two-dimensional matrix relating the biomarker categories on one axis to four different types of activities (laboratory, transitional, and etiological studies and public health applications) that develop markers and apply them in human populations. We then use the matrix to review the potential application of biomarkers in observational studies of cancer etiology, discussing the advantages, disadvantages, and logistical considerations in using biomarkers to answer research questions. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biomarkers Environmental Monitoring Neoplasms Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Biological-effects Biological-factors Biological-monitoring Cancer-rates Exposure-assessment Exposure-levels Exposure-methods Immune-system Immune-system-disorders Mathematical-models Pathogenicity Risk-factors Statistical-analysis

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• ISSN:
  1055-9965
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; Ohio ; OSHA Region 3 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  301-311
• Volume:
  4
• Issue:
  4
• NIOSHTIC Number:
  nn:20035610
• Citation:
  Cancer Epidemiol Biomark Prev 1995 Jun; 4(4):301-311
• Contact Point Address:
  N Rothman, National Cancer Institute, Environmental Epidemiology Branch, Occupation Studies Section, EPN 418, 6130 Executive Boulevard, MSC 7364, Bethesda, MD 20892
• Federal Fiscal Year:
  1995
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Epidemiology, Biomarkers & Prevention
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d19417b26522bfb61952f196ad70fdc751f07e13583af703fc3e5827bca9ae6a24d500a92396c32391bdd82eaa5af4d8d7291459449e5e67f518e1f51a8251a3
• Download URL:
  https://stacks.cdc.gov/view/cdc/187409/cdc_187409_DS1.pdf
• File Type:
  [PDF - 2.23 MB ]