A Nested Case-Control Study of Multiple Myeloma Risk and Uranium Exposure Among Workers at the Oak Ridge Gaseous Diffusion Plant

Details

• Personal Author:
  Anderson, Jeri L. ; Chen PH ; Daniels, Robert D. ; Fleming DA ; Seel EA ; Waters, Kathy M. ; Yiin JH
• Description:
  The primary risk factors of multiple myeloma are age, race and sex, but several studies have found an association between radiological hazards and multiple myeloma. The purpose of this nested case-control study was to investigate whether workers with chronic low-level exposure to internally deposited uranium at the Oak Ridge Gaseous Diffusion Plant in eastern Tennessee were at higher risk of dying of multiple myeloma than those without occupational exposure to uranium, with the consideration of potential confounders of external ionizing radiation and occupational chemical hazards such as mercury, nickel and trichloroethylene. The main analyses were carried out using conditional logistic regression on 98 cases and 490 controls (five controls matched to each case on gender, race and age at risk). Our study showed a weak association between internal uranium dose estimated from urinalysis results and multiple myeloma risk: OR = 1.04 (95% CI 1.00-11.09) at 10 mu Gy with the inclusion of other risk factors. The parameter estimates and the corresponding odds ratios were very similar when internal doses were imputed for subjects without urine samples. Further studies that include updating this cohort and combining with workers from other gaseous diffusion plants are needed to investigate the relationship between multiple myeloma risk and radiation or other chemical exposures. [Description provided by NIOSH]
• Subjects:
  Age Factors Biological Factors Chemistry Hypersensitivity Neoplasms Occupational Exposure Occupational Health Race Factors Radiation Radiation Injuries Safety Sex Characteristics Skin Skin Diseases Workplace

  More +
• Keywords:
  Age-factors Biological-factors Cancer Chemical-hypersensitivity Chemical-properties Chemical-reactions Exposure-levels Exposure-limits Exposure-methods Ionization Ionizing-radiation Nuclear-radiation Occupational-exposure Occupational-hazards Racial-factors Radiation-effects Radiation-exposure Radiation-hazards Radiation-injury Radiation-levels Radiation-properties Radiation-sources Sex-factors Skin-cancer Skin-diseases Statistical-analysis Work-environment Work-operations Worker-health Workplace-studies

  More +
• ISSN:
  0033-7587
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  171
• Issue:
  6
• NIOSHTIC Number:
  nn:20035535
• Citation:
  Radiat Res 2009 Jun; 171(6):637-645
• Contact Point Address:
  JH Yiin, NIOSH, DSHEFS, 4676 Columbia Pakway, MS R-15, Cincinnati, OH 45226
• Email:
  JYiin@cdc.gov
• CAS Registry Number:
  Mercury (CAS RN 7439-97-6) ; Nickel (CAS RN 7440-02-0) ; Trichloroethylene (CAS RN 79-01-6)
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  True
• Source Full Name:
  Radiation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d8735b71792b9fd9b4e9bc8241a09b840bcbc9820a0dd48e87edb7fecbe2f72b9dc66ddc7a5ac1b1e2d33498d30e3f019990971d57e0fafdf4a52dbb701c995
• Download URL:
  https://stacks.cdc.gov/view/cdc/187361/cdc_187361_DS1.pdf
• File Type:
  [PDF - 256.65 KB ]