Numerical Simulations Investigating the Regional and Overall Deposition Efficiency of the Human Nasal Cavity

Details

• Personal Author:
  Ahmadi G ; Cheng YS ; Hopke PK ; Shanley KT ; Zamankhan P
• Description:
  Numerical simulations have been carried out on a model of the right passageway of an anonymous, adult male's nasal cavity, constructed from magnetic resonance imagery (MRI) scans. Steady, laminar, inspiratory flow was assumed to simulate inhalation. Analysis shows smoothly varying streamlines with a peak in velocity magnitude occurring in the nasal valves and a peak in vorticity magnitude immediately posterior. Dilute, uniform concentrations of inertial (1 microm < or = d(ae) < or = 10 microm) particles were released at the nostril and tracked via a Lagrangian tracking algorithm. Deposition efficiency is shown to increase with particle size and flow rate. Preferential deposition is seen in the anterior third of the nasal cavity for large Stokes number particles. An empirical expression for particle deposition is proposed that incorporates particle size, flow rate, and nose anatomy. [Description provided by NIOSH]
• Subjects:
  Aerosols Air Movements Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Dust Environmental Monitoring Ergonomics Irritants Laboratories Musculoskeletal System Nose Occupational Health Particulate Matter Respiratory Function Tests Respiratory Hypersensitivity Respiratory System Safety Sense Organs

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• Keywords:
  Aerosol-particles Air-contamination Air-flow Air-monitoring Air-quality Air-sampling Air-sampling-techniques Breathing Fibrous-dusts Inhalation-studies Laboratory-techniques Laboratory-testing Mathematical-models Models Nasal-cavity Nasal-disorders Particle-aerodynamics Particle-counters Particulate-dust Particulate-sampling-methods Posture Qualitative-analysis Respirable-dust Respiration Respiratory-function-tests Respiratory-hypersensitivity Respiratory-irritants Statistical-analysis

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• ISSN:
  0895-8378
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  12
• NIOSHTIC Number:
  nn:20035420
• Citation:
  Inhal Toxicol 2008 Sep; 20(12):1093-1100
• Contact Point Address:
  Prof. Goodarz Ahmadi, Clarkson University, Department of Mechanical and Aeronautical Engineering, 8 Clarkson Avenue, Potsdam, NY 13699-5700
• Email:
  ahmadi@clarkson.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Lovelace Biomedical & Environmental Research
• Peer Reviewed:
  True
• Start Date:
  20020901
• Source Full Name:
  Inhalation Toxicology
• End Date:
  20080831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e3c8226be9214b2e63ccf8946f4e96f966024173cbd257f72f39455ee038c3383c562c4870f2541c85cca3ad72fd4893444d6af1b10d0ec01844d8f45c9fe79e
• Download URL:
  https://stacks.cdc.gov/view/cdc/187282/cdc_187282_DS1.pdf
• File Type:
  [PDF - 2.80 MB ]