Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Lack, Justin B. ; Volk, Kylie ; Van Den Bussche, Ronald A. ;
Lack, Justin B. ; Volk, Kylie ; Van Den Bussche, Ronald A. ; Less -
Description:
The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.
Subject:
[+]
Animals
Animals, Wild
Genotype
Hepatitis E
Hepatitis E Virus
Liver
Phylogeny
Rats
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
Sequence Analysis, DNA
Zoonoses

Source:
Emerg Infect Dis. 18(8):1268-1273. ;
Document Type:
Journal Article ;
Place as Subject:
United States ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:70eae1dc2f83abde4c4e14d7840567ad95b149c01cc764c98c20c5a2893cc26e
File Type:

Supporting Files

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  	12-0070.nxml	txt
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