Hepatitis E Virus Genotype 3 in Wild Rats, United States

Lack, Justin B.; Volk, Kylie; Van Den Bussche, Ronald A.

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Hepatitis E Virus Genotype 3 in Wild Rats, United States

Published Date:

Aug 2012

Source:

Emerg Infect Dis. 18(8):1268-1273.

[PDF-327.93 KB]

Details:

Personal Authors:

Lack, Justin B. ; Volk, Kylie ; Van Den Bussche, Ronald A. ;

Keywords:

[+]

Description:

The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

	12-0070-F.gif	image/gif
	12-0070-F.jpg	image/jpeg
	12-0070-FA1.gif	image/gif
	12-0070-FA1.jpg	image/jpeg
	12-0070.nxml	text/plain
	12-0070_Techapp-s1.xls	application/vnd.ms-excel

No Related Documents.

You May Also Like:

Hepatitis E Virus in Rats, Los Angeles, California, USA

Personal Author:

Purcell, Robert H.; Engle, Ronald E.; Rood, Michael P.; Kabrane-Lazizi, Yamina; Nguyen, Hanh T.; Govindarajan, Sugantha; St. Claire, Marisa; Emerson, Suzanne U.;

Published:

Dec 2011

Source:

Emerg Infect Dis. 17(12):2216-2222.

Description:

The role of rats in human hepatitis E virus (HEV) infections remains controversial. A genetically distinct HEV was recently isolated from rats in Germany, and its genome was sequenced. We have isolated a genetically similar HEV from urban rats in Los...

File Type:

[PDF - 257.57 KB]
No Evidence for Hepatitis E Virus Genotype 3 Susceptibility in Rats

Personal Author:

Li, Tian-Cheng; Ami, Yasushi; Suzaki, Yuriko; Takeda, Naokazu; Takaji, Wakita;

Published:

Aug 2013

Source:

Emerg Infect Dis. 19(8):1343-1345.

File Type:

[PDF - 352.75 KB]
Novel Hepatitis E Virus Genotype in Norway Rats, Germany

Personal Author:

Johne, Reimar; Heckel, Gerald; Plenge-Bönig, Anita; Kindler, Eveline; Maresch, Christina; Reetz, Jochen; Schielke, Anika; Ulrich, Rainer G.;

Published:

Sep 2010

Source:

Emerg Infect Dis. 16(9):1452-1455.

Description:

Human hepatitis E virus infections may be caused by zoonotic transmission of virus genotypes 3 and 4. To determine whether rodents are a reservoir, we analyzed the complete nucleotide sequence of a hepatitis E-like virus from 2 Norway rats in Germany...

File Type:

[PDF - 329.54 KB]
Asian Musk Shrew as a Reservoir of Rat Hepatitis E Virus, China

Personal Author:

Guan, Dawei; Li, Wei; Su, Juan; Fang, Ling; Takeda, Naokazu; Wakita, Takaji; Li, Tian-Cheng; Ke, Changwen;

Published:

Aug 2013

Source:

Emerg Infect Dis. 19(8):1341-1343.

File Type:

[PDF - 354.71 KB]
Consensus proposals for classification of the family Hepeviridae

Personal Author:

Smith, Donald B.; Simmonds, Peter; Jameel, Shahid; Emerson, Suzanne U.; Harrison, Tim J.; Meng, Xiang-Jin; Okamoto, Hiroaki; Van der Poel, Wim H. M.; Purdy, Michael A.;

Corporate Author:

members of the International Committee on the Taxonomy of Viruses Hepeviridae Study Group

Published:

Jul 02 2014

Source:

J Gen Virol. 95(Pt 10):2223-2232.

Description:

The family Hepeviridae consists of positive-stranded RNA viruses that infect a wide range of mammalian species, as well as chickens and trout. A subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chro...

File Type:

[PDF - 627.00 KB]