Hepatitis E Virus Genotype 3 in Wild Rats, United States

Lack, Justin B.; Volk, Kylie; Van Den Bussche, Ronald A.

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Hepatitis E Virus Genotype 3 in Wild Rats, United States

Published Date:

Aug 2012

Source:

Emerg Infect Dis. 18(8):1268-1273.

[PDF - 327.93 KB]

Details:

Personal Authors:

Lack, Justin B. ; Volk, Kylie ; Van Den Bussche, Ronald A. ;

Keywords:

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Description:

The role of rodents in the epidemiology of zoonotic hepatitis E virus (HEV) infection has been a subject of considerable debate. Seroprevalence studies suggest widespread HEV infection in commensal Rattus spp. rats, but experimental transmission has been largely unsuccessful and recovery of zoonotic genotype 3 HEV RNA from wild Rattus spp. rats has never been confirmed. We surveyed R. rattus and R. norvegicus rats from across the United States and several international populations by using a hemi-nested reverse transcription PCR approach. We isolated HEV RNA in liver tissues from 35 of 446 rats examined. All but 1 of these isolates was relegated to the zoonotic HEV genotype 3, and the remaining sequence represented the recently discovered rat genotype from the United States and Germany. HEV-positive rats were detected in urban and remote localities. Genetic analyses suggest all HEV genotype 3 isolates obtained from wild Rattus spp. rats were closely related.

Document Type:

Journal Article

Collection(s):

Emerging Infectious Diseases

Supporting Files:

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