Association of Cumulative Lead and Neurocognitive Function in an Occupational Cohort

Details

• Personal Author:
  Cauley JA ; Khalil N ; Morrow LA ; Needleman H ; Talbott EO ; Wilson JW
• Description:
  Lead is a neurotoxicant that accumulates in bone with a half life of 25-30 years. To evaluate the association of lead biomarkers and cognitive function, a cohort of exposed and nonexposed workers who had been previously assessed in 1982 was retested approximately 22 years later. For the current assessment, both blood lead and tibia bone lead levels were determined. In addition, cognitive function was tested with the Pittsburgh Occupational Exposures Test battery, which had previously been administered in 1982. In exposed workers, bone lead level predicted lower current cognitive performance and cognitive decline over 22 years. In those lead-exposed workers older than age 55, higher levels of bone lead predicted poorer cognitive scores, suggesting vulnerability for older workers with higher past lead exposure. Finally, there was no association with bone lead level and recency of exposure, suggesting that cumulative body burden is most likely responsible for the progressive cognitive decrement evidenced with vulnerability because of aging. [Description provided by NIOSH]
• Subjects:
  Age Factors Biomarkers Demography Environmental Monitoring Epidemiology Lead Metals Musculoskeletal Diseases Musculoskeletal System Nervous System Occupational Health Safety

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• Keywords:
  Age-factors Biologic-half-life Biological-effects Biological-monitoring Bone-disorders Demographic-characteristics Exposure-assessment Exposure-levels Lead-compounds Metal-compounds Neuropathology Psychophysiology Skeletal-system-disorders

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• ISSN:
  0894-4105
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  10-19
• Volume:
  23
• Issue:
  1
• NIOSHTIC Number:
  nn:20035279
• Citation:
  Neuropsychology 2009 Jan; 23(1):10-19
• Contact Point Address:
  Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Work Environment and Workforce: Special Populations
• Performing Organization:
  University of Pittsburgh, Pittsburgh, Pennsylvania
• Peer Reviewed:
  True
• Start Date:
  20000930
• Source Full Name:
  Neuropsychology
• End Date:
  20040929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f403929891042434ddde24d48fae61e4ffd162a755467c5c4925d86c70f4c2e2fa50a881bf8d0faeb6cacccc9d96450efb3e3760602c425ca31d46b1fb6d237a
• Download URL:
  https://stacks.cdc.gov/view/cdc/187190/cdc_187190_DS1.pdf
• File Type:
  [PDF - 132.04 KB ]