4-Oxopentanal Identified as a Potential Indoor Air Irritant and Allergen

Details

• Personal Author:
  Anderson, Stacey E. ; Butterworth L ; Franko JL ; Ham J ; Jackson L ; Munson AE ; Wells R
• Description:
  Over the last two decades, there has been an increasing awareness regarding the potential impact of indoor air pollution on human health. People working in an indoor environment often experience symptoms such as eye, nose and throat irritation, headache, and fatigue. Investigations into these complaints have ascribed the effects to volatile organic compounds (VOC) emitted from building materials, cleaning formulations or other consumer products, and indoor chemistry. The dicarbonyl 4-Oxopentanal (4-OPA) is generated through the ozonolysis of squalene and several high volume production compounds that are commonly found indoors. Measureable levels of 4-OPA have been detected in simulated indoor air environments. 4-OPA was tested in a combined local lymph node assay (LLNA) and identified to be an irritant and extreme sensitizer with an EC3 value of 0.08%. Significant increases were observed in the B220+ and IgE+B220+ cell populations in the draining lymph nodes after exposure to 4-OPA concentrations of 6.25% and higher. Total serum IgE levels were also significantly elevated after exposure to 25% 4-OPA. These results suggest that 4-OPA may function as an IgE-mediated sensitizer. The identification of this compound as an irritant and sensitizer may help to explain some of the adverse health effects associated with indoor air exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollution Air Pollution, Indoor Biological Factors Environmental Health Environmental Monitoring Hazardous Substances Hypersensitivity Irritants Lung Occupational Exposure Occupational Health Respiratory Hypersensitivity Respiratory System Safety Workplace

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• Keywords:
  Air-monitoring Air-quality Air-quality-measurement Air-quality-monitoring Air-sampling Biological-effects Biological-factors Biological-monitoring Chemical-hypersensitivity Exposure-methods Health-hazards Indoor-environmental-quality Inhalation-studies Occupational-exposure Occupational-health Organic-chemicals Organic-compounds Pulmonary-system Respiratory-hypersensitivity Respiratory-irritants Work-environment Workplace-studies

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• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  108
• Issue:
  1
• NIOSHTIC Number:
  nn:20035272
• Citation:
  Toxicologist 2009 Mar; 108(1):313
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Healthcare and Social Assistance ; Services
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 48th Annual Meeting and ToxExpo, March 15-19, 2009, Baltimore, Maryland
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:587f5f2b02bdc7dd59175c66fdd550659ce732f3f176a3678f478b636323225004f1edebc9f8e55dd757258fd4bf1acbf3904baa16e253d3ba1318dbea3a2c4f
• Download URL:
  https://stacks.cdc.gov/view/cdc/187186/cdc_187186_DS1.pdf
• File Type:
  [PDF - 1.58 MB ]