Positive Associations Between Ionizing Radiation and Lymphoma Mortality Among Men

Details

• Personal Author:
  Geyer S ; Grant E ; Kasagi F ; Kodama K ; Nishi N ; Richardson DB ; Sakata R ; Shimizu Y ; Soda M ; Sugiyama H ; Suyama A ; Wing S
• Description:
  The authors investigated the relation between ionizing radiation and lymphoma mortality in 2 cohorts: 1) 20,940 men in the Life Span Study, a study of Japanese atomic bomb survivors who were aged 15-64 years at the time of the bombings of Hiroshima and Nagasaki, and 2) 15,264 male nuclear weapons workers who were hired at the Savannah River Site in South Carolina between 1950 and 1986. Radiation dose-mortality trends were evaluated for all malignant lymphomas and for non-Hodgkin's lymphoma. Positive associations between lymphoma mortality and radiation dose under a 5-year lag assumption were observed in both cohorts (excess relative rates per sievert were 0.79 (90% confidence interval: 0.10, 1.88) and 6.99 (90% confidence interval: 0.96, 18.39), respectively). Exclusion of deaths due to Hodgkin's disease led to small changes in the estimates of association. In each cohort, evidence of a dose-response association was primarily observed more than 35 years after irradiation. These findings suggest a protracted induction and latency period for radiation-induced lymphoma mortality. [Description provided by NIOSH]
• Subjects:
  Explosions Mining Occupational Health Safety Vibration
• Keywords:
  Author Keywords: Lymphoma Cancer Cancer-rates Epidemiology Ionizing Lymphatic-cancer Lymphatic-system-disorders Lymphocytes Mortality Mortality-data Mortality-rates Nuclear Weapons Occupational-diseases Radiation Radiation-therapy Risk-analysis Statistical-analysis

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• ISSN:
  0002-9262
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  8
• NIOSHTIC Number:
  nn:20035215
• Citation:
  Am J Epidemiol 2009 Apr; 169(8):969-976
• Contact Point Address:
  David B. Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435
• Email:
  david.richardson@unc.edu
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Performing Organization:
  University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
• Peer Reviewed:
  True
• Start Date:
  20020930
• Source Full Name:
  American Journal of Epidemiology
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:313fc50a0086564f40dfd7e6aac0423ed424ce6c8d94ceea3db0282963491505cd8da9c4da683bf2a2126edb157c91773387aa3f8108782bc07d0672ada0cc86
• Download URL:
  https://stacks.cdc.gov/view/cdc/187140/cdc_187140_DS1.pdf
• File Type:
  [PDF - 97.19 KB ]