Manganese Exposure Among Smelting Workers: Blood Manganese-Iron Ratio as a Novel Tool for Manganese Exposure Assessment

Details

• Personal Author:
  Aschner M ; Chen J ; Cowan DM ; Fan Q ; Rosenthal FS ; Shi X ; Zheng W ; Zou Y
• Description:
  Unexposed control subjects (n = 106), power distributing and office workers (n = 122), and manganese (Mn)-exposed ferroalloy smelter workers (n = 95) were recruited to the control, low and high groups, respectively. Mn concentrations in saliva, plasma, erythrocytes, urine and hair were significantly higher in both exposure groups than in the controls. The Fe concentration in plasma and erythrocytes, however, was significantly lower in Mn-exposed workers than in controls. The airborne Mn levels were significantly associated with Mn/Fe ratio (MIR) of erythrocytes (eMIR) (r = 0.77, p < 0.01) and plasma (pMIR) (r = 0.70, p < 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population. [Description provided by NIOSH]
• Subjects:
  Biological Factors Biomarkers Energy Metabolism Environmental Health Ferrous Compounds Hazardous Substances Manganese Occupational Exposure Occupational Health Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety Toxicology

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• Keywords:
  Author Keywords: Manganese Biological-effects Biological-factors Biomarker Environmental-health Erythrocyte Exposure Assessment Iron Iron-oxide-fumes Manganese-compounds Metabolism Mn-Fe Ratio Occupational-exposure Occupational-hazards Occupational-health Occupational-respiratory-disease Pulmonary-system-disorders Quantitative-analysis Risk-factors Saliva Smelter Statistical-analysis Toxic-effects Toxins

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Indiana ; OSHA Region 4 ; OSHA Region 5 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  3-16
• Volume:
  14
• Issue:
  1
• NIOSHTIC Number:
  nn:20035103
• Citation:
  Biomarkers 2009 Feb; 14(1):3-16
• Contact Point Address:
  Wei Zheng, Professor of Health Sciences and Toxicology, Purdue University School of Health Sciences, 550 Stadium Mall Drive, CIVL-1163D, West Lafayette, Indiana 47907
• Email:
  wzheng@purdue.edu
• CAS Registry Number:
  Iron (CAS RN 7439-89-6) ; Manganese (CAS RN 7439-96-5)
• Federal Fiscal Year:
  2009
• Performing Organization:
  Purdue University, West Lafayette, Indiana
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Biomarkers
• End Date:
  20270630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e0ff284e01077b05d44aec16275023c119d5d26652ffb63216e62f05addaf90a30b42b61d0337abcd75529133751b3a24ed3887245c1072f442d8be23c56d841
• Download URL:
  https://stacks.cdc.gov/view/cdc/187067/cdc_187067_DS1.pdf
• File Type:
  [PDF - 1.02 MB ]