Serum Growth Factors in Asbestosis Patients

Details

• Personal Author:
  Brandt-Rauf PW ; Hemminki K ; Karjalainen A ; Koskinen H ; Li Y ; Pukkala E ; Vainio H
• Description:
  Various growth factors, including platelet-derived growth factor (PDGF) and transforming growth factor (TGF)-beta, have been implicated in the pathogenesis of asbestos-induced disease. PDGF and TGF-beta levels were determined by enzyme-linked immunosorbent assays in the banked serum samples of a cohort of workers with asbestosis, and the relationships of the growth factor levels to the subsequent development of cancer and to the radiographic severity and progression of asbestosis in the cohort were examined. Serum levels of PDGF and TGF-beta were found to be unrelated to the development of cancer, and serum levels of PDGF were found to be unrelated to the severity and progression of asbestosis. However, serum levels of TGF-beta were found to be statistically significantly related to disease severity (p = 0.01), increasing approximately 2.4-fold from ILO radiographic category 0 to category 3, and they were marginally related to disease progression (p = 0.07), in multivariate analysis controlling for other contributory factors including cumulative asbestos exposure. This suggests that serum TGF-beta may be a useful biomarker for asbestos-induced fibrotic disease. [Description provided by NIOSH]
• Subjects:
  Asbestos Biomarkers Carcinogens Environmental Monitoring Epidemiology Growth Inorganic Chemicals Lung Lung Diseases Mutagens Neoplasms Occupational Health Radiation Respiratory System Respiratory Tract Diseases Risk Assessment Risk Factors Safety

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• Keywords:
  Asbestos-industry Asbestos-workers Author Keywords: PDGF Cancer Cancer-rates Carcinogenesis Carcinogenicity Disease-incidence Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Growth-factors Growth-rate Lung-cancer Lung-disease Mathematical-models Mutagenesis Pathogenesis Pathogenicity Pneumoconiosis Pneumoconiosis Progression Pneumoconiosis Severity Pulmonary-cancer Pulmonary-system-disorders Radiation-effects Radiation-exposure Risk-analysis Risk-factors TGF

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  61-66
• Volume:
  14
• Issue:
  1
• NIOSHTIC Number:
  nn:20035102
• Citation:
  Biomarkers 2009 Feb; 14(1):61-66
• Contact Point Address:
  Paul Brandt-Rauf, Office of the Dean, School of Public Health, University of Illinois at Chicago, 1603 West Taylor Street, Room 1145, Chicago, IL 60612
• Email:
  pwb1@uic.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Performing Organization:
  Columbia University Health Sciences
• Peer Reviewed:
  True
• Start Date:
  20020601
• Source Full Name:
  Biomarkers
• End Date:
  20110630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d958745fd7054539bd2dc01d5425bcbfc43b34f077459edbcd0e43bb61ee1ff76d908a6884edf805f4b61d2f9e2dad26966641f3cd658fa6c4860726bf1cb97
• Download URL:
  https://stacks.cdc.gov/view/cdc/187066/cdc_187066_DS1.pdf
• File Type:
  [PDF - 673.17 KB ]