Silicosis in the Lymph Nodes: The Canary in Miner

Details

• Personal Author:
  Andrew, Michael E. ; Burchfiel CM ; Cox-Ganser, Jean M. ; Ducatman BS ; Fekedulegn D ; Andrew, Michael E. ; Burchfiel CM ; Cox-Ganser, Jean M. ; Ducatman BS ; Fekedulegn D
• Description:
  Objectives: to investigate evidence that lymph node silicosis can precede parenchymal silicosis. Methods: the study population was comprised of 264 deceased male uranium miners for whom two or more of four pathologists agreed on the presence or absence of silicosis in lymph nodes and lung parenchyma. We had work histories and silica exposure estimates. Results: twenty percent of the miners had lymph node silicosis only, 4% had parenchymal silicosis only, and 39% had both. Silica exposure was lower for miners with lymph node silicosis only than for those with both lymph node and parenchymal silicosis. Lymph node silicosis was associated with parenchymal silicosis after adjustment for silica exposure. Conclusions: our results are consistent with silicosis potentially occurring in lymph nodes before the parenchyma. Lymph node damage could impair silica clearance and increase the risk for parenchymal silicosis. [Description provided by NIOSH]
• Subjects:
  Epidemiology Mining Occupational Health Respiratory Tract Diseases Safety Silicon Dioxide Uranium Workplace
• Keywords:
  Lymph-nodes Lymphatic-system Miners Mining-industry Pulmonary-system-disorders Respiratory-system-disorders Silica-dusts Silicate-miners Statistical-analysis Uranium-mining Work-environment

  More +
• ISSN:
  1076-2752
• Document Type:
  Text
• Genre:
  Journal Article ; Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH) ; National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies ; HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies ; HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health ; Workplace Safety & Health
• Location:
  North America ; North America
• Pages in Document:
  164-169
• Volume:
  51
• Issue:
  2
• NIOSHTIC Number:
  nn:20035071
• Citation:
  J Occup Environ Med 2009 Feb; 51(2):164-169
• Contact Point Address:
  Jean Cox-Ganser, PhD, CDC, NIOSH, Division of Respiratory Disease Studies, 1095 Willowdale Road, Suite H-2800, Morgantown, WV 26508
• Email:
  jjc8@cdc.gov
• CAS Registry Number:
  Silicon (CAS RN 7440-21-3) ; Silicon (CAS RN 7440-21-3)
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:374a88639c7b4a998ec560e6f16f08e077a6438972f48a9a298360d71b00146eee6fcb76ed8fb0c6a1f1044ba519a1be41519e7738fce51f33c98e18ae3a1b99
• Download URL:
  https://stacks.cdc.gov/view/cdc/187050/cdc_187050_DS1.pdf
• File Type:
  [PDF - 174.17 KB ]