Reproductive and Developmental Effects Associated with Chronic Arsenic Exposure

Details

• Personal Author:
  Browning S ; Ferreccio C ; Hertz-Picciotto I ; Hopenhayn-Rich C ; Peralta C
• Description:
  Chronic exposure to inorganic arsenic is known to cause cancer and non-cancer health effects in humans. The evidence from animal studies clearly shows that arsenic is teratogenic, and the findings of limited human studies suggest that inorganic arsenic may be associated with several reproductive/developmental outcomes, including increased rates of spontaneous abortion, Low birth weight, congenital malformations, pre-eclampsia and infant mortality. The city of Antofagasta, located in northern Chile, has a history of high arsenic exposure in drinking water. Due to changes in the sources of water, there were considerably high arsenic levels in the public drinking water supply from 1958 to 1970 , which decreased gradually to the current concentrations . A number of studies have reported various health effects associated with the high exposure period, induding skin alterations typically linked to arsenic exposure and increases in bladder and lung cancer. We conducted an ecologic study of infant mortality rates in Chile from 1950 to 1996, comparing Antofagasta to low arsenic exposure areas.Temporal and cross-regional comparisons showed a general steady decline over time in late fetal, neonatal and postneonatal mortality rates for all locations, consistent with improvements in standard of living and health care. However, comparatively high rates were observed in Antofagasta for the three outcomes studied during the 12 year period of highest arsenic exposure, compared to Santiago and Valparaiso, two locations used as reference groups. While not definitive, these findings support a role for arsenic in the ob rved increases in mortality rates. Given the worldwide public health concern for arsenic effects, more population studies are needed in the area of human reproductive and developmental effects. [Description provided by NIOSH]
• Subjects:
  Arsenic Chemistry Drinking Water Education Environment Environmental Exposure Environmental Health Environmental Monitoring Environmental Pollution Hazardous Substances Hypersensitivity Inorganic Chemicals Mortality Occupational Health Poisoning Public Health Risk Assessment Risk Factors Safety Stress, Psychological Urogenital Diseases Urogenital System Waste Management Water Purification

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• Keywords:
  Arsenic-compounds Arsenic-herbicides Arsenic-poisoning Arsenites Author Keywords: Arsenic Chemical-agent-detectors Chemical-analysis Chemical-composition Chemical-hypersensitivity Chemical-indicators Chemical-inhibition Chemical-properties Chemical-reactions Chemical-structure Chemical-synthesis Children Chile Developmental Effects Drinking-water Drinking Water Educational-resource-centers Environment Environmental-contamination Environmental-control Environmental-exposure Environmental-factors Environmental-hazards Environmental-health Environmental-health-monitoring Environmental-physiology Environmental-pollution Environmental-protection Environmental-stress Environmental-technology Exposure-levels Exposure-limits Exposure-methods Hazardous-materials Hazardous-waste-cleanup Hazards Hazards-Confirmed Infant Mortality Mortality-data Mortality-rates Mortality-surveys Public-health Reproduction Reproductive-effects Reproductive-hazards Reproductive-system-disorders Risk-analysis Risk-factors Waste-treatment Water-analysis Water-industry Water-purification Water-sampling

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• ISBN:
  9780412734700
• Publisher:
  Elsivier Science
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Book
• Place as Subject:
  Kentucky ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  151-164
• NIOSHTIC Number:
  nn:20034994
• Citation:
  Arsenic exposure and health effects. Chappell WR, Abernathy CO, Calderon RL, eds. New York: Chapman & Hall, 1999 Jan; :151-164
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Editor(s):
  Chappell WR; Abernathy CO; Calderon RL
• Federal Fiscal Year:
  1999
• Performing Organization:
  University of Kentucky
• Peer Reviewed:
  False
• Start Date:
  20010930
• Source Full Name:
  Arsenic exposure and health effects
• End Date:
  20270929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:45864aa3c1b6b67df66331194303ca781a6b85c1c8ff26f2e60131a3b26abaebee9ee8c392e429be71149db3082f238d8506a1b50eaece621a441a2f21dbd6f9
• Download URL:
  https://stacks.cdc.gov/view/cdc/187000/cdc_187000_DS1.pdf
• File Type:
  [PDF - 35.65 MB ]