Cross-Talk Between Lung and Systemic Circulation During Carbon Nanotube Respiratory Exposure. Potential Biomarkers

Details

• Personal Author:
  Castranova, Vincent ; Endo M ; Erdely A ; Hulderman T ; Kim YA ; Koyama S ; Liston A ; Salmen R ; Schwegler-Berry D ; Simeonova PP ; Zeidler-Erdely PC
• Description:
  Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure. [Description provided by NIOSH]
• Subjects:
  Biomarkers Dust Genetics Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Genes Nanotechnology Pulmonary-system-disorders Respirable-dust Respiratory-system-disorders
• ISSN:
  1530-6984
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  36-43
• Volume:
  9
• Issue:
  1
• NIOSHTIC Number:
  nn:20034966
• Citation:
  Nano Lett 2009 Jan; 9(1):36-43
• Email:
  Psimeonova@cdc.gov
• Federal Fiscal Year:
  2009
• Peer Reviewed:
  True
• Source Full Name:
  Nano Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e5027d00c682a4bf42df44e71d114b52ddf97c118e72d3bc2d1ddb4622409d97f2c2dce4cc26f5fadbe47fac1ae127919976e77c6a8cb1e849346056cca9c6aa
• Download URL:
  https://stacks.cdc.gov/view/cdc/186973/cdc_186973_DS1.pdf
• File Type:
  [PDF - 2.16 MB ]