Cytokine Polymorphisms and Relationship to Disease

Details

• Personal Author:
  Johnson VJ ; Kashon ML ; Luster MI ; Yucesoy, Berran
• Description:
  Cytokines are polypeptide mediators produced by a variety of cell types that play crucial roles in immune and inflammatory responses. Genes that code for cytokines are highly polymorphic, and some of these polymorphisms directly or indirectly influence cytokine expression. The most frequent types of mutations are characterized by a change in a single nucleotide base pair and are called single nucleotide polymorphisms (SNPs). Many SNPs that affect cytokine expression represent disease modifiers and influence the severity or progression of immune-mediated and chronic inflammatory diseases. SNPs in cytokine genes have been associated with common diseases, including cardiovascular diseases, cancer, neurodegenerative diseases, allergy, and asthma, and data are now accumulating on their role in occupational/environmental diseases. All these diseases are multigenic and multifactorial in nature and involve interactions between genetic, physiological, and environmental factors. Currently, there exist inconsistencies in association studies examining relationships between cytokine SNPs and disease because of known limitations in population-based studies. Recent advances in geno typing platforms for large-scale genetic studies, more robust study designs, and haplotype analysis should help reduce the amount of spurious and inconsistent associations in the literature and allow for incorporating genetic information into the risk assessment process although challenges still remain. [Description provided by NIOSH]
• Subjects:
  Environmental Health Genetics Occupational Health Safety
• Keywords:
  Author Keywords: Cytokine Autoimmune Diseases Cell-function Cellular-function Common Diseases Environmental-factors Epidemiology Genetic-factors Occupational Diseases Physiology Polymorphism SNP

  More +
• ISBN:
  9781588294678
• ISSN:
  1557-2153
• Publisher:
  Humana Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  113-132
• NIOSHTIC Number:
  nn:20034846
• Citation:
  Cytokines in human health: immunotoxicology, pathology, and therapeutic applications. House RV, Descotes J, eds. Totowa, NJ: Humana Press, 2007 Apr; :113-132
• Editor(s):
  House RV; Descotes J
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  False
• Source Full Name:
  Cytokines in human health: immunotoxicology, pathology, and therapeutic applications
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ad7dd192737a22f6de4e6a2d9a559b953a22149287f49ea1fe6b9192f7ffd57c90c7944e08fc22d619e4d9e015ecce788bbed5af6275547a5d984ea4394d5163
• Download URL:
  https://stacks.cdc.gov/view/cdc/186900/cdc_186900_DS1.pdf
• File Type:
  [PDF - 138.34 KB ]