Urinary 8-Isoprostane and 8-OHdG Concentrations in Boilermakers with Welding Exposure

Details

• Personal Author:
  Boyce PD ; Cavallari JM ; Christiani, David C. ; Eisen EA ; Fang SC ; Nuernberg AM
• Description:
  OBJECTIVE: To investigate the association of exposure to fine particulate matter (PM2.5) with DNA damage and oxidative stress in boilermakers exposed to welding fumes. METHODS: Forty-one workers were monitored over 24 hours during which baseline, postshift, bedtime, and next morning measurements were collected. Twenty-two workers participated as controls. RESULTS: Linear regression was used to model pairwise change in u-8-isoprostane and u-8-OHdG: pre- to postshift, preshift to bedtime, postshift to bedtime, and postshift to next morning. In the models, pre- to postshift change in 8-OHdG was statistically significant, whereas postshift to bedtime change in 8-isoprostane showed an unexpected inverse relationship with PM2.5. CONCLUSIONS: Acute welding exposure is associated with a postshift blunting of systemic inflammation in chronically exposed boilermakers, as measured by 8-isoprostane. The level of oxidative DNA damage as measured by 8-OHdG is less clear. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational DNA Occupational Exposure Occupational Health Oxidants Particulate Matter Safety Urine Welding
• Keywords:
  DNA-damage Fumes Occupational-exposure Oxidative-metabolism Particle-aerodynamics Particulates Statistical-analysis Urinalysis Welders Welding-industry
• ISSN:
  1076-2752
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  182-189
• Volume:
  50
• Issue:
  2
• NIOSHTIC Number:
  nn:20034718
• Citation:
  J Occup Environ Med 2008 Feb; 50(2):182-189
• Contact Point Address:
  David Christiani, MD, MPH, MS, Department of Environmental Health, Harvard School of Public Health, Massachusetts General Hospital/Harvard Medical School, 665 Huntington Avenue, Building 1, Room 1407, Boston, MA 02115
• Email:
  dchris@hohp.harvard.edu
• Federal Fiscal Year:
  2008
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  Journal of Occupational and Environmental Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3ca3cbe38e18e51394518f87bff1806eae60950fa92c0a00a99c03d9138cd3d0b431873dd212046177f7f5058266beb4d876a4ab44b60d9acb96932fb06ab069
• Download URL:
  https://stacks.cdc.gov/view/cdc/186824/cdc_186824_DS1.pdf
• File Type:
  [PDF - 256.33 KB ]