Evaluation of Body Mass Index, Pre-Vaccination Serum Progesterone Levels and Anti-Anthrax Protective Antigen Immunoglobulin G on Injection Site Adverse Events Following Anthrax Vaccination in Women

Details

• Personal Author:
  Biagini, Raymond E. ; Franzke LH ; Martin SW ; McNeil MM ; Robertson SA ; Rose CE Jr. ; Sammons DL ; Smith JP ; Zhang Y
• Description:
  Background: in 2002, CDC initiated the Anthrax Vaccination Program (AVP) to provide voluntary pre-exposure anthrax vaccination for individuals at high risk for exposure to Bacillus anthracis spores. The AVP offered an opportunity to investigate hypothesized reasons for a reported gender difference in injection site adverse events (AEs) following anthrax vaccine adsorbed (AVA). Objectives: to evaluate in women the impact of body mass index (BMI), pre-vaccination serum progesterone levels, and pre-vaccination anti-anthrax protective antigen immunoglobulin G concentrations (anti-PA IgG) on the occurrence of AEs following subcutaneous AVA vaccination. Methods: participants' BMI was determined at enrollment. Also, pre-vaccination blood samples were assayed for serum progesterone and anti-PA IgG. Post-vaccination solicited AEs were recorded by participants using a 4-day diary card. Results: obese group had an elevated risk for arm soreness. Decreased pre-vaccination serum progesterone level was associated with arm swelling. Increased pre-vaccination anti-PA IgG was associated with itching on the arm; and within the obese group, was associated with arm swelling, lump or knot, redness, soreness, and warmth. Conclusions In AVA vaccinated women, obesity was associated with arm soreness and decreased pre-vaccination serum progesterone levels were associated with increased rate of arm swelling. Increased pre-vaccination anti-PA IgG may be associated with an increased frequency of itching on the arm, and in obese women, may increase the occurrence of arm swelling, lump or knot, redness, and warmth. Administering AVA according to a woman's menstrual phase may reduce the occurrence of certain injection site reactions. [Description provided by NIOSH]
• Subjects:
  Biological Factors Body Weight Immune System Occupational Health Safety Women
• Keywords:
  Biological-effects Biological-factors Body-weight Immune-reaction Immune-system Immunological-tests Vaccines
• ISSN:
  1053-8569
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  17
• Issue:
  11
• NIOSHTIC Number:
  nn:20034697
• Citation:
  Pharmacoepidemiol Drug Saf 2008 Nov; 17(11):1060-1067
• Contact Point Address:
  Michael M. McNeil, Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, MS C-25, Atlanta, GA 30333
• Email:
  mmm2@cdc.gov
• Federal Fiscal Year:
  2009
• NORA Priority Area:
  Healthcare and Social Assistance ; Manufacturing
• Peer Reviewed:
  True
• Source Full Name:
  Pharmacoepidemiology and Drug Safety
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3d5ba678d807acba0e7ea2c991751f4fb0b8764002cd2700114521d44c41635dabcdcaa970046262d1c12d89e7142d30625c66fa3abf37748f4662d440cef253
• Download URL:
  https://stacks.cdc.gov/view/cdc/186809/cdc_186809_DS1.pdf
• File Type:
  [PDF - 86.12 KB ]