Peripheral Neuritis and Increased Spinal Cord Neurochemicals Are Induced in a Model of Repetitive Motion Injury with Low Force and Repetition Exposure

Details

• Personal Author:
  Al-Shatti T ; Amin M ; Barbe MF ; Barr AE ; Elliott MB ; Kietrys DM
• Description:
  Performance of high repetition tasks with or without force is associated with peripheral tissue inflammation, decreased nerve function and motor dysfunction. Here, we examined whether a low repetition task with negligible force (LRNF) produces fewer tissue and behavioral pathologies than previously observed with high repetition tasks using our rat model of repetitive motion injury (RMI). Thirty-seven rats were randomized into control or LRNF groups, the latter reaching and grasping a 45 mg food pellet at a rate of 3 reaches/min. This task was performed in 4, 0.5 5 h sessions with 1.5 5 h rest periods for 3 days/week for up to 12 weeks. Examination of distal median nerve, forelimb flexor tendons and bones for ED1-positive cells (macrophages and osteoclasts) revealed increases in nerve and bone in week 12. The nerve also contained increased TNF-alpha expressing cells in week 12. Examination of spinal cord dorsal horns revealed increased immunoexpression of Substance P in week 8 and neurokinin-1 in weeks 8 and 12 in the superficial lamina. Motor behavioral analyses showed no changes in reach rate across weeks, slightly reduced task duration (a measurement of voluntary task participation) in week 12, but significantly increased extra arm movement reversals during reaching in week 8. These extra movement reversals were corrections for missed food pellets during a reach. Thus, performance of even a low repetition, negligible force upper extremity task for 3 months can induce mild peripheral tissue inflammation, neurochemical increases in spinal cord dorsal horns, and declines in fine motor control. [Description provided by NIOSH]
• Subjects:
  Epidemiology Laboratories Musculoskeletal Diseases Nervous System Nervous System Diseases Occupational Health Safety Sense Organs
• Keywords:
  Diseases Injuries Laboratory-animals Laboratory-testing Motion-studies Musculoskeletal-system-disorders Neurological-diseases Neuromotor-disorders Neuromotor-function Neuromotor-system Neuromotor-system-disorders Neuromuscular-system-disorders Repetitive-work Sensory-disorders Sensory-motor-system Spinal-cord

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• ISSN:
  0006-8993
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New Jersey ; OSHA Region 2 ; OSHA Region 3 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  103-113
• Volume:
  1218
• NIOSHTIC Number:
  nn:20034627
• Citation:
  Brain Res 2008 Jul; 1218:103-113
• Contact Point Address:
  Mary F. Barbe, Department of Physical Therapy, College of Health Professions, Department of Anatomy and Cell Biology, Temple Medical School, Temple University, 3307 North Broad St., Philadelphia, PA 19140
• Email:
  mary.barbe@temple.edu
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing ; Construction
• Performing Organization:
  Temple University
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Brain Research
• End Date:
  20120731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8b9d65f73538789e982671686fcb8b1f39a78bfbfac3cd312f1184a22b543c638c5470aec5bafd6f9d2913a792c0c2f7ff422a55347a1309445a30fac8e3ae4
• Download URL:
  https://stacks.cdc.gov/view/cdc/186766/cdc_186766_DS1.pdf
• File Type:
  [PDF - 1.53 MB ]