Entrapment of Ionic tris(2,2′-Bipyridyl) ruthenium(II) in Hydrophobic Siliceous Zeolite: O2 Sensing in Biological Environments

Details

• Personal Author:
  Dutta PK ; Nagy A ; Ruda-Eberenz TA ; Waldman WJ
• Description:
  Synthesis of the ionic dye, tris(2,2'-bipyridyl) ruthenium(II) chloride (Ru(bpy)32+·2Cl-) within the supercages of a highly hydrophobic zeolite Y is reported. Use of the neutral precursor Ru(bpy)Cl2(CO)2 allowed for high loading levels of Ru(bpy)32+ (1 per 7 and 25 supercages). The emission quenching of the Ru(bpy)32+-zeolite crystals dispersed in polydimethoxysiloxane (PDMS) films by dissolved oxygen in water was examined. The quenching data as a function of oxygen concentration was fit to a linear Stern-Volmer plot (R2 = 0.98). Using the Stern-Volmer plot as calibration, changes in concentration of dissolved oxygen due to reaction with glucose in the presence of glucose oxidase was monitored. Human monocyte-derived macrophages internalized the submicron-sized Ru(bpy)32+-zeolite crystals, and intracellular oxygen concentrations initiated by zymosan-mediated oxidative burst could be monitored by measuring the emission from Ru(bpy)32+ by confocal fluorescence microscopy. [Description provided by NIOSH]
• Subjects:
  Biological Factors Metals Occupational Health Particulate Matter Safety
• Keywords:
  Biological-factors Biological-systems Metallic-compounds Oxygen-transport Particulate-dust Particulates
• ISSN:
  0743-7463
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  16
• NIOSHTIC Number:
  nn:20034579
• Citation:
  Langmuir 2008 Aug; 24(16):9140-9147
• Contact Point Address:
  Prabir K. Dutta, Department of Pathology, The Ohio State University College of Medicine, 4160 Graves Hall, 333 West 10th Avenue, Columbus, OH 43210
• CAS Registry Number:
  Glucose (CAS RN 50-99-7) ; Oxygen (CAS RN 7782-44-7) ; Zeolites, synthetic (CAS RN 1318-02-1)
• Federal Fiscal Year:
  2008
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  The Ohio State University
• Peer Reviewed:
  True
• Start Date:
  20060801
• Source Full Name:
  Langmuir
• End Date:
  20100731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0a28fb7e61a547cf265ba334c35fa92c2e01953d21e04fa95af8f1c5430d5f5abbfe51755d500f8c61cfff7f9ffdfea2cc6a060675a014c65a7fc57388417d79
• Download URL:
  https://stacks.cdc.gov/view/cdc/186737/cdc_186737_DS1.pdf
• File Type:
  [PDF - 780.21 KB ]