In Utero Exposure to DDT and Performance on the Brazelton Neonatal Behavioral Assessment Scale

Details

• Personal Author:
  Anderson M ; Barr DB ; Bradman A ; Eskenazi B ; Fenster L ; Hubbard A
• Description:
  We investigated whether decrements in neonatal neurodevelopment, as determined by the Brazelton neonatal behavioral assessment scale (BNBAS), were associated with in utero exposure to dichlorodiphenyltrichloroethane (DDT): p,p'-dichlorodiphenyl trichloroethane (p,p'-DDT), o,p'-dichlorodiphenyl trichloroethane (o,p'-DDT) and p,p'-DDT's primary breakdown product p,p'-dichlorodiphenyl dichloroethylene (p,p'-DDE) (heretofore collectively referred to as DDT/DDE). Our subjects were a birth cohort of 303 infants whose mothers were low-income Latinas living in the Salinas Valley, an agricultural community in California. We assessed neonates < or =2 months old using the seven BNBAS clusters (habituation, orientation, motor performance, range of state, regulation of state, autonomic stability, and reflex) and examined performance in relationship to DDT/DDE measures in maternal serum samples collected during pregnancy. We did not find any detrimental associations between in utero DDT/DDE levels and neonatal performance on the BNBAS. In this same cohort, we previously demonstrated that exposures to DDT/DDE were related to decrements in neurodevelopment at 6-24 months of age. The failure to observe effects on the BNBAS in these same children may be due to limited sensitivity of a single BNBAS assessment or a delay in the manifestations of neurodevelopmental effects of DDT/DDE until after the neonatal period. [Description provided by NIOSH]
• Subjects:
  Agriculture Environmental Monitoring Hazardous Substances Nervous System Occupational Health Pregnancy Risk Assessment Risk Factors Safety
• Keywords:
  Agricultural-chemicals Biological-monitoring Children Exposure-assessment Exposure-levels Health-hazards Neurological-system Prenatal-exposure Risk-analysis Risk-factors Sensitivity-testing

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• ISSN:
  0161-813X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; Georgia ; OSHA Region 4 ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  471-477
• Volume:
  28
• Issue:
  3
• NIOSHTIC Number:
  nn:20032781
• Citation:
  Neurotoxicology 2007 May; 28(3):471-477
• Contact Point Address:
  Laura Fenster, California Department of Health Services, Division of Environmental and Occupational Disease Control, 850 Marina Bay Parkway, Richmond, CA 94804-6403
• Email:
  lfenster@dhs.ca.gov
• CAS Registry Number:
  1,1′-Biphenyl, chloro derivs. (CAS RN 1336-36-3)
• Federal Fiscal Year:
  2007
• Performing Organization:
  University of California, Berkeley
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Neurotoxicology
• End Date:
  20060929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7bb046eea3aa3b9dca420ab6de71f909cbaf729ccb4b9f932d8c17a0ac4ee340d61671bf041b237def2d0061260637da9dbb5fb4489c8a1c9cb915db171927b4
• Download URL:
  https://stacks.cdc.gov/view/cdc/186626/cdc_186626_DS1.pdf
• File Type:
  [PDF - 151.60 KB ]