Polycyclic Aromatic Hydrocarbon Biomarkers of Internal Exposure in US Army Soldiers Serving in Kuwait in 1991

Details

• Personal Author:
  Deeter DP ; Heller JM ; Jacobson-Kram D ; McDiarmid MA ; Pan CF ; Poirier MC ; Rothman N ; Schoket B ; Scott BG ; Shamkhani H ; Weston A
• Description:
  Biomarkers of exposure were applied to a cohort of U.S. Army soldiers who were deployed to Kuwait and Saudi Arabia in 1991 in the aftermath of the Persian Gulf War. The U.S. Army Environmental Hygiene Agency (currently the U.S Army Center for Health Promotion and Preventive Medicine) monitored air and soil for ambient PAHs. In addition, a group of 61 soldiers kept diaries of daily activities. These soldiers provided blood and urine samples in June in Germany before deployment to Kuwait, in August after 8 weeks in Kuwait, and in October, one month after the return to Germany. DNA, prepared from white blood cells, was assayed for PAH-DNA adducts by immunoassay and bulky aromatic adducts by P-32-postlabeling, Urinary 1-hydroxypyrene-glucuronide (1-OH-PG) was determined by synchronous fluorescence spectrometry. Contrary to expectations, environmental monitoring showed low ambient PAH levels in the areas where these soldiers were working in Kuwait. In addition, literature values for ambient PAH monitoring in Germany in 1990 suggest that the soldiers may have been exposed to higher levels of ambient PAHs in Germany than in Kuwait. Blood cell DNA adduct levels were lowest in Kuwait and increased significantly after the return to Germany. Also, urinary 1-OH-PG levels were lowest in Kuwait and highest in Germany. This study demonstrates modulations in PAH exposure biomarker levels that appear to correlate with ambient PAH exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Biomarkers Environmental Monitoring Occupational Health Safety Urine
• Keywords:
  Air-contamination Air-monitoring Air-quality Air-quality-measurement Air-sampling Air-sampling-techniques Military-personnel Urinalysis Urine-chemistry
• ISSN:
  1040-6638
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Alabama ; Kansas ; Maryland ; New York ; OSHA Region 2 ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 7 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  197-208
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:20032751
• Citation:
  Polycycl Aromat Compd 1999 Jan; 17(1-4):197-208
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Polycyclic Aromatic Compounds
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6a7b6ec9ec96b6bc0b5ea7d8f7ab52a3eaa5d4f8d0284d934dfe43407ed2570e7020a53adf28e84c3875ec9a160de425a6969cf026603a54c470b25e140c36a9
• Download URL:
  https://stacks.cdc.gov/view/cdc/186605/cdc_186605_DS1.pdf
• File Type:
  [PDF - 942.91 KB ]