Characterization of Dust Exposure for the Study of Chronic Occupational Lung Disease: A Comparison of Different Exposure Assessment Strategies

Details

• Personal Author:
  Attfield, Michael ; Heederik D
• Description:
  Various exposure assessment strategies were compared in the study of the relation between dust exposure and 11-year lung function change in 1,172 miners with 36,824 concurrently measured personal dust samples available from the 1969-1981 US National Study of Coal Workers' Pneumoconiosis. A miner's average exposure was assessed by calculating average exposures based on dust samples taken from each individual and by using different job exposure matrices (JEMs) with different underlying exposure categorizations, based on occupational categories, job title, mine, and time, to obtain average exposure estimates. For each grouping procedure, intragroup and intergroup variances and the pooled standard error of the mean were calculated to assess relative efficiency. The results show that considerable variation in slopes of exposure-response relations was found using different exposure assessment strategies. Standard errors of the slopes of the exposure-response relations with exposure on an individual basis compared with JEMs, Exposure assessment on an individual basis was extremely sensitive to the number of exposure measurements per individual. The study demonstrates the advantages and disadvantages of different exposure assessment strategies and shows the need for explicit publication of exposure assessment strategies for epidemiologic studies. Careful assessment of the influence of misclassification error in the exposure assessment on exposure-response modeling is warranted. [Description provided by NIOSH]
• Subjects:
  Dust Epidemiology Mining Occupational Health Particulate Matter Safety
• Keywords:
  Author Keywords: Forced Expiratory Volume Dust Particles Exposure Assessment Lung Diseases Miners Mining Industry Obstructive Occupational Diseases Pneumoconiosis Respiratory Function Tests
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  151
• Issue:
  10
• NIOSHTIC Number:
  nn:20032727
• Citation:
  Am J Epidemiol 2000 May; 151(10):982-990
• Contact Point Address:
  Dr. Dick J. J. Heederik, Department of Environmental Sciences, Environmental and Occupational Health Group, University of Wageningen, P.O. Box 238,6700 AE Wageningen, Netherlands
• Email:
  Dick.Heederik@Staff.eoh.wau.nl
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8a03f36069487a18e85bbf58717712fd220f15e39af216c4a2c8cd92f2226975ccacbcfa9aa59a672ec1f5ba08522c8d12865a8ab8f35c51ff1ef126ce0ee978
• Download URL:
  https://stacks.cdc.gov/view/cdc/186594/cdc_186594_DS1.pdf
• File Type:
  [PDF - 830.37 KB ]