A TGF-Beta 1 Polymorphism Association with Dementia and Neuropathologies: The HAAS

Details

• Personal Author:
  Johnson V ; Kashon ML ; Launer LJ ; Luster M ; Peila R ; Petrovitch H ; White LR ; Wu K ; Yucesoy, Berran
• Description:
  The transforming growth factor-beta 1 (TGF-beta 1) is involved in post-ischemic neuronal rescue and in P-amyloid turn-over. We hypothesized that the risk for dementia and related neuropathologies is modified by the TGF-beta 1 functional genetic variants. The association of the TGF-beta 1 + 29T ->) C polymorphism with dementia was examined in a sample of 261 cases and 491 controls from the Honolulu-Asia Aging Study, including 282 subjects with autopsy data. Dementia was assessed in 1991 and 1994 by a multi-step protocol and standardized diagnostic criteria. The analysis was adjusted for demographic and vascular factors. Compared to the TT genotype, the TC and the CC genotypes were associated with a reduced risk for vascular dementia (ORTC = 0.28, 95% confidence interval (CI): 0. 1-0.9; ORcc = 0.28, CI: 0. 1-0.9), microinfarcts (ORCC = 0.3 1, CI: 0. 13-0.7 1) and cerebral amyloid angiopathy (ORCC = 0.48, CI: 0.2-0.9). The CC genotype was associated with an increase risk of neocortical plaques (ORCC =4.34, CI: 1.6-11.8). These preliminary data suggest that the TGF genetic variability may be important in the risk of vascular related dementia. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Mental Disorders Mental Health Nervous System Nervous System Diseases Occupational Health Safety
• Keywords:
  Brain-function Cerebrovascular-system-disorders Mental-disorders Mental-health Physiological-factors Physiological-function Physiological-measurements Physiological-testing
• ISSN:
  0197-4580
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Hawaii ; Maryland ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  28
• Issue:
  9
• NIOSHTIC Number:
  nn:20032694
• Citation:
  Neurobiol Aging 2007 Sep; 28(9):1367-1373
• Contact Point Address:
  Rita Peila, Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, National Institutes of Health, 7201 Wisconsin Avenue, Suite 3C-309, Bethesda, MD 20892-9205
• Email:
  peilar@mail.nih.gov
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Neurobiology of Aging
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1880870cbfd43d7673314a3ec283d766f9c98042c3603ff9b78769167c04eedd4b74d0d6137a32d8e4f2a7fcd62e9cc8a343ce3a4bd814e6d9c9d15c7db78dd7
• Download URL:
  https://stacks.cdc.gov/view/cdc/186576/cdc_186576_DS1.pdf
• File Type:
  [PDF - 126.21 KB ]