Dust Generator for Inhalation Studies with Limited Amounts of Archived Particulate Matter

Details

• Personal Author:
  Aust AE ; Pinkerton KE ; Teague SV ; Veranth JM
• Description:
  A novel design for a dry-aerosol generator that efficiently produces a well-dispersed dust suspension using small quantities of a PM2.5-enriched powder sample is described. The motivation to develop a highly efficient dry-aerosol particle generator was to facilitate collaborative projects that combine in vitro cell culture experiments and multiday inhalation exposures using a single batch of well-characterized particles. Premixing of the test particles with larger diameter glass beads permits delivery of aerosol concentrations from 100-1000 g/m3 to an exposure chamber using only milligram quantities of the test powder per hour. Examination of exposure chamber filter samples by scanning electron microscopy showed well-dispersed particles of the test powder free of glass spheres or fragments. Data are presented from experiments using coal fly ash as the test powder to illustrate the system performance. [Description provided by NIOSH]
• Subjects:
  Aerosols Dust Microbiology Occupational Health Safety
• Keywords:
  Aerosol-generators Aerosol-particles Dust-collectors Dust-counting Dust-exposure Dust-inhalation Dust-measurement Electron-absorption-spectrometry Microscopic-analysis
• ISSN:
  0278-6826
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 8 ; OSHA Region 9 ; Utah
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85-91
• Volume:
  39
• Issue:
  2
• NIOSHTIC Number:
  nn:20032523
• Citation:
  Aerosol Sci Technol 2005 Feb; 39(2):85-91
• Contact Point Address:
  Stephen V. Teague: University of California Davis, Davis, California, USA
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Work Environment and Workforce: Special Populations
• Performing Organization:
  University of California, Davis, California
• Peer Reviewed:
  True
• Start Date:
  19970101
• Source Full Name:
  Aerosol Science and Technology
• End Date:
  19991231
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:300335f9bf691cc08e654fd11d9be6ac3c035ef111cc95f373e2d48df96374026ffd8ab1c6b84668175234979186d732949a6ae5748d9d7cabe763880d69ad9d
• Download URL:
  https://stacks.cdc.gov/view/cdc/186460/cdc_186460_DS1.pdf
• File Type:
  [PDF - 1.26 MB ]