Estimating Active Bone Marrow Dose from Occupational Exposure to Uranium at a Former Gaseous Diffusion Plant

Details

• Personal Author:
  Anderson, Jeri L. ; Spitz HB ; Yiin JH
• Description:
  Active bone marrow absorbed doses were estimated for 581 workers as part of a nested case-control study of multiple myeloma mortality at the Oak Ridge Gaseous Diffusion Plant (K-25). Uranium urinalysis results obtained by fluorometric and gross alpha measurements were available for about 20% of the 581 study subjects. These data were used to determine intakes of uranium as a result of occupational exposure during operation of the K-25 facility. Uranium solubility was inferred from the observed urinary excretion rate, job titles, and department codes. Data suggest that most study subjects were exposed to uranyl fluoride, a relatively soluble uranium compound. The median cumulative bone marrow dose determined for subjects with bioassay data was 0.06 mGy with a geometric standard deviation of 4.48. Subjects without bioassay data were assigned cumulative bone marrow dose based upon job titles and department codes. [Description provided by NIOSH]
• Subjects:
  Epidemiology Metals, Heavy Mortality Musculoskeletal System Neoplasms Occupational Health Radiation Safety Uranium
• Keywords:
  Bone-marrow Cancer Cancer-rates Heavy-metals Mortality-data Mortality-rates Nuclear-hazards Nuclear-radiation Radiation-exposure Radiation-facilities Radiation-measurement Statistical-analysis Uranium-compounds Uranium-ore

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• ISSN:
  0017-9078
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 4 ; OSHA Region 5 ; Tennessee
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  113-119
• Volume:
  93
• Issue:
  3
• NIOSHTIC Number:
  nn:20032400
• Citation:
  Health Phys 2007 Aug; 93(2):113-119
• Contact Point Address:
  Division of Surveillance, Hazard Evaluation, and Field Studies (DSHEFS), National Institute for Occupational Safety and Health (NIOSH), Cincinnati, OH 45226, USA
• Email:
  JLAnderson@cdc.gov
• CAS Registry Number:
  Uranium (CAS RN 7440-61-1)
• Federal Fiscal Year:
  2007
• Peer Reviewed:
  True
• Source Full Name:
  Health Physics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b9e83990cb411a79da7b0c024997b66ead4cb3f1e90a7c1e25742c76c2c1710e976429cdb58e204086a7d49204d7759a36f32ef7bf7ab5eb99925df64061e8a
• Download URL:
  https://stacks.cdc.gov/view/cdc/186394/cdc_186394_DS1.pdf
• File Type:
  [PDF - 266.19 KB ]