Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Piepenbring, Anne K. ; Enderlein, Dirk ; Herzog, Sibylle ; Kaleta, Erhard F. ; Heffels-Redmann, Ursula ; ... More +
Piepenbring, Anne K. ; Enderlein, Dirk ; Herzog, Sibylle ; Kaleta, Erhard F. ; Heffels-Redmann, Ursula ; Ressmeyer, Saskia ; Herden, Christiane ; Lierz, Michael Less -
Description:
Avian bornavirus (ABV) is the presumed causative agent of proventricular dilatation disease (PDD), a major fatal disease in psittacines. However, the influencing factors and pathogenesis of PDD are not known and natural ABV infection exhibits remarkable variability. We investigated the course of infection in 18 cockatiels that were intracerebrally and intravenously inoculated with ABV. A persistent ABV infection developed in all 18 cockatiels, but, as in natural infection, clinical disease patterns varied. Over 33 weeks, we simultaneously studied seroconversion, presence of viral RNA and antigens, infectious virus, histopathologic alterations, and clinical signs of infection in the ABV-infected birds. Our study results further confirm the etiologic role of ABV in the development of PDD, and they provide basis for further investigations of the pathogenetic mechanisms and disease-inducing factors for the development of PDD.
Subject:
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Animals
Antibodies, Viral
Avian Bornavirus
Bird Diseases
Bornaviridae
Bornavirus Disease
Central Nervous System
Cockatiels
Cockatoos
Experimental Infection
Female
Genes, Viral
Male
Mononegavirales Infections
Pathogenesis
Proventricular Dilatation Disease
Proventriculus
Psittacines
Research
RNA, Viral
Sequence Analysis, DNA
Skin
Virus

Source:
Emerg Infect Dis. 18(2):234-241.
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:8e0ac051392375768a2e67e96f21b60dd7d49cdef363ea87607effa44c9ba32a
File Type:

Supporting Files

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