Serum Levels of the Extracellular Domain of the Epidermal Growth Factor Receptor in Individuals Exposed to Arsenic in Drinking Water in Bangladesh

Details

• Personal Author:
  Ahsan H ; Brandt-Rauf PW ; Chen Y ; Graziano JH ; Li Y ; Parvez F ; Slavkovic V
• Description:
  Epidermal growth factor receptor-dependent mechanisms have been implicated in growth signal transduction pathways that contribute to cancer development, including dermal carcinogenesis. Detection of the extracellular domain of the epidermal growth factor receptor (EGFR ECD) in serum has been suggested as a potential biomarker for monitoring this effect in vivo. Arsenic is a known human carcinogen, producing skin and other malignancies in populations exposed through their drinking water. One such exposed population, which we have been studying for a number of years, is in Bangladesh. The purpose of this study was to examine the EGFR ECD as a potential biomarker of arsenic exposure and/or effect in this population. Levels of the EGFR ECD were determined by enzyme-linked immunosorbent assay in the serum samples from 574 individuals with a range of arsenic exposures from drinking water in the Araihazar area of Bangladesh. In multiple regression analysis, serum EGFR ECD was found to be positively associated with three different measures of arsenic exposure (well water arsenic, urinary arsenic and a cumulative arsenic index) at statistically significant levels (p
• Subjects:
  Biomarkers Carcinogens Dermatitis Environmental Monitoring Epidemiology Immune System Mutagens Neoplasms Occupational Health Risk Assessment Risk Factors Safety Skin Skin Diseases Water Purification

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• Keywords:
  Cancer Cancer-rates Carcinogenesis Carcinogenicity Dermatosis Exposure-assessment Exposure-levels Exposure-limits Exposure-methods Immune-reaction Mathematical-models Mutagenesis Risk-analysis Risk-factors Skin-cancer Skin-disorders Skin-exposure Skin-lesions Tumors Water-analysis

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• ISSN:
  1354-750X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  New York ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  256-265
• Volume:
  12
• Issue:
  3
• NIOSHTIC Number:
  nn:20032313
• Citation:
  Biomarkers 2007 May-Jun; 12(3):256-265
• Contact Point Address:
  PW Brandt-Rauf, Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 60 Haven Avenue, B-1, New York, NY 10032
• Email:
  pwb1@columbia.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2007
• NORA Priority Area:
  Manufacturing
• Performing Organization:
  Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
• Peer Reviewed:
  True
• Start Date:
  20010701
• Source Full Name:
  Biomarkers
• End Date:
  20150831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:df9de2b0e8adbc8b16dc6eb720e4883d2e0897618fe818f2e6263151114969369ed3268566fe8a423097d4c32031f73c3efd12fd25264323cad0703fd39c7225
• Download URL:
  https://stacks.cdc.gov/view/cdc/186336/cdc_186336_DS1.pdf
• File Type:
  [PDF - 240.27 KB ]