Size Exclusion Chromatographic Cleanup for GC/MS Determination of Organophosphorus Pesticide Residues in Household and Vehicle Dust

Details

• Personal Author:
  Curl C ; Fenske RA ; Furia M ; Moate TF ; Muniz JF ; Yu J
• Description:
  Size exclusion chromatography (SEC) was used as a cleanup method for the analysis of organophosphorus pesticides in household and vehicle dusts. The pesticides investigated were diazinon, methyl parathion, chlorpyrifos, malathion, phosmet, and azinphosmethyl. These compounds are of interest due to their use in agricultural tree fruit production and/or urban pest control. Pesticides were determined via gas chromatography/mass spectrometry with selected-ion monitoring and cool on-column injection. The lower limit of method validation was 0.20 microg/g. Method limits of detection in dust ranged from 0.012-0.055 microg/g. Dust samples were collected with vacuums from the homes and vehicles of people living and working in a rural agricultural region in the central part of Washington State. The analytes were extracted from the dust by sonication in acetone. The extracts were solvent-exchanged to cyclohexane, frozen, thawed, and centrifuged prior to SEC injection. Following SEC, the eluent was split into 2 fractions, concentrated, and injected on-column into the gas chromatograph. This method represents the first complete publication describing the SEC cleanup of organophosphorus pesticides in dusts. Recoveries of pesticides in dusts ranged from 63.5-110.8 +/- 4.9-19.6% over a fortification range of 0.20-10.00 microg/g. This optimized, automated, and reproducible SEC method does not require further treatment or cleanup for trace determination of these organophosphorus pesticides [Description provided by NIOSH]
• Subjects:
  Agriculture Dust Environmental Monitoring Insecticides Occupational Health Organophosphates Safety
• Keywords:
  Agricultural-chemicals Agricultural-industry Agricultural-products Agricultural-workers Dust-analysis Dust-collection Dust-exposure Exposure-assessment Exposure-limits Organo-phosphorus-compounds Organo-phosphorus-pesticides Pesticides Samplers Sampling Treatment

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• ISSN:
  1060-3271
• Document Type:
  Text
• Funding:
  Cooperative Agreement
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  36-43
• Volume:
  85
• Issue:
  1
• NIOSHTIC Number:
  nn:20032232
• Citation:
  J AOAC Int 2002 Jan-Feb; 85(1):36-43
• Contact Point Address:
  University of Washington, Environmental Health Laboratory, Seattle 98195-7234
• Email:
  tmoate@snblusa.com
• CAS Registry Number:
  Azinphos-methyl (CAS RN 86-50-0) ; Chlorpyrifos (CAS RN 2921-88-2) ; Cyclohexene (CAS RN 110-83-8) ; Diazinon (CAS RN 333-41-5) ; Malathion (CAS RN 121-75-5) ; Parathion-methyl (CAS RN 2Furfuryl alcohol (CAS RN 98-00-0)) ; Phosmet (CAS RN 732-11-6)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Neurotoxic Disorders ; Neurotoxic Effects
• Performing Organization:
  University of Washington
• Peer Reviewed:
  True
• Start Date:
  19960930
• Source Full Name:
  Journal of AOAC International
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:49fe33da2ff7c5cceddb7b854dafb66f8c0fd749f197f88e9c4d6715acf06d934c73a8f1b65fac68623536d29a7632f469a3194c4869d5b4cc902b8658543ef4
• Download URL:
  https://stacks.cdc.gov/view/cdc/186265/cdc_186265_DS1.pdf
• File Type:
  [PDF - 69.72 KB ]